SelectedWorks - Edward Calabrese

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Selected Works of Edward Calabrese

Professor, Environmental Health Sciences

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About Edward Calabrese

Present	Professor, Environmental Health Sciences, University of Massachusetts Amherst
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environmental toxicology and emphasis on biological factors (i.e. genetic and nutritional factors) which enhance susceptibility to pollutant toxicity

Environmental Health Science
Morrill Science Center I, N340
University of Massachusetts Amherst
Tel: 413-545-3164

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Articles (21)

Article

Model Uncertainty via the Integration of Hormesis and LNT as ...

Dose-Response: An International Journal (2015)

Edward Calabrese

On June 23, 2015, the US Nuclear Regulatory Commission (NRC) issued a formal notice in the Federal Register that it ...

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Article

Historical foundations of wound healing and its potential

Wound Repair and Regeneration (2013)

Edward Calabrese

ABSTRACT This paper provides a detailed historical assessment of the origin and developmental progress of the concept of wound healing ...

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Article

Stress Responses, Vitagenes and Hormesis as Critical Determinants in Aging ...

Immunity and Ageing (2013)

Carolin Cornelius, Rosario Perrotta, Antonio Graziano, Edward J. Calabrese, et al.

Understanding mechanisms of aging and determinants of life span will help to reduce age-related morbidity and facilitate healthy aging. Average ...

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Article

A Method to Evaluate Hormesis in Nanoparticle Dose-Responses

Dose-Response (2012)

Marc A Nascarella and Edward J Calabrese

The term hormesis describes a dose-response relationship that is characterized by a response that is opposite above and below the ...

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Article

Hormesis and the Salk Polio Vaccine

Dose-Response (2012)

Edward J Calabrese

The production of the Salk vaccine polio virus by monkey kidney cells was generated using the synthetic tissue culture medium, ...

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Article

The Role of X-Rays in the Treatment of Gas Gangrene ...

Dose-Response (2012)

Edward J Calabrese and Gaurav Dhawan

While the use of x-rays to treat patients with gas gangrene ended in the early 1940’s with the advent of ...

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Article

Exposure to Nanoparticles and Hormesis

Dose-Response (2010)

Ivo Iavicoli, Edward C. Calabrese and Marc A. Nascarella

Nanoparticles are particles with lengths that range from 1 to 100 nm. They are increasingly being manufactured and used for ...

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Article

Predicting Low Dose Effects for Chemicals in High Through-Put Studies

Dose-Response (2010)

Edward J Calabrese and Edward J Stanek, III

High through-put studies commonly use automated systems with 96-well plates in which multiple chemicals are tested at multiple doses using ...

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Article

Tumor Resistance Explained by Hormesis

Dose-Response (2010)

Edward J Calabrese and Marc A Nascarella

Enhanced drug (GDC 0449) resistance in a mouse model for human medulloblastoma is shown in the present paper to act ...

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Article

Quantification of Hormesis in Anticancer-Agent Dose-Response

Dose-Response (2009)

Marc A Nascarella, Edward J Stanek, III, George R Hoffmann and Edward J Calabrese

Quantitative features of dose responses were analyzed for 2,189 candidate anticancer agents in 13 strains of yeast (Saccharomyces cerevisiae). The ...

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Article

Chloramphenicol, European Legislation and Hormesis - Commentary

Dose-Response (2007)

Jaap C Hanekamp and Edward J Calabrese

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Article

The Importance of Hormesis to Public Health

Environmental Health Perspectives (EHP) (2006)

Robert Cook and Edward J. Calabrese

Background: Hormesis is a specific type of nonmonotonic dose response whose occurrence has been documented across a broad range of ...

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Article

Hormesis and stage specific toxicity induced by cadmium in an ...

Environ. Poll. (2003)

Marc A. Nascarella, John G. Stoffolano, Jr., Edward J. Stanek, III, Paul T. Kostecki, et al.

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Article

Hormesis at the National Toxicology Program (NTP): Evidence of Hormetic ...

Nonlinearity in Biology, Toxicology, and Medicine (2003)

Edward J Calabrese and Linda A Baldwin

The National Toxicology Program (NTP) dose-ranging studies typically employ five dosages and a concurrent control and are conducted for 2- ...

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Article

Hormesis: The Dose-response Revolution

Annual Review of Pharmacology and Toxicology (2003)

Edward J. Calabrese and Linda A. Baldwin

Hormesis, a dose-response relationship phenomenon characterized by low-dose stimulation and high-dose inhibition, has been frequently observed in properly designed studies ...

Article

The Maturing of Hormesis as a Credible Dose-Response Model

Nonlinearity in Biology, Toxicology, and Medicine (2003)

Edward J Calabrese

Hormesis is a dose-response phenomenon that has received little recognition, credibility and acceptance as evidenced by its absence from major ...

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Article

U-Shaped Dose-Responses in Biology, Toxicology, and Public Health

Annual Review of Public Health (2001)

Edward J. Calabrese and Linda A. Baldwin

The occurrence of U-shaped dose-response relationships (often termed hormesis) has been documented in numerous biological, toxicological, and pharmacological investigations. Many ...

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Article

Hormesis as a Biological Hypothesis

Environmental Health Perspectives (EHP) (1998)

Edward J. Calabrese and Linda A. Baldwin

A comprehensive effort was undertaken to identify articles demonstrating chemical hormesis. Nearly 4000 potentially relevant articles were retrieved from preliminary ...

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Article

Soil Ingestion: A Concern for Acute Toxicity in Children

Environmental Health Perspectives (EHP) (1997)

Edward J. Calabrese, Edward J. Stanek, Robert C. James and Stephen M. Roberts

Several soil ingestion studies have indicated that some children ingest substantial amounts of soil on given days. Although the EPA ...

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Article

Daily Estimates of Soil Ingestion in Children

Environmental Health Perspectives (EHP) (1995)

Edward J. Stanek, III and Edward J. Calabrese

Soil ingestion estimates play an important role in risk assessment of contaminated sites, and estimates of soil ingestion in children ...

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Article

A Toxicological Basis to Derive a Generic Interspecies Uncertainty Factor

Environmental Health Perspectives (EHP) (1994)

Edward J. Calabrese and Linda A. Baldwin

The use of an uncertainty factor (UF) to account for interspecies variation in risk assessment procedures for noncarcinogens is well ...

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Book

Risk Assessment and Environmental Fate Methodologies

(1992)

Edward J. Calabrese and Paul T. Kostecki

Book

Petroleum Contaminated Soils, Volume 1: Remediation Techniques Environmental Fate Risk ...

(1989)

Paul T. Kostecki and Edward J. Calabrese

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Book

Petroleum Contaminated Soils: Redmediation Techniques Environmental Fate Risk Assessment

(1989)

Paul T. Kostecki and Edward J. Calabrese

Calabrese and Hormesis: A Biography and Autobiography

About Edward Calabrese

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Articles (21)

Books (3)

Presentations (1)