A new medium-sized species of leptodactylid frog, genus Phrynopus is described from the puna of the eastern Andean slopes of central Peru (Departamento de Huanuco, 3 770m above sea level). The new species differs from all described species of the genus by having a pale brownish orange dorsal coloration, and a pale cream to orange ventral coloration. The new species lacks ear and vomerine teeth, and is most similar to P barthlenae with which it occurs sympatrically. Males of the new species are unknown.