Research Interests: Interactions between cells and their extracellular environment play an essential role in controlling tissue architecture, cell survival, and cell migration. These processes are important for normal animal development and are disrupted in many human diseases. The Cram lab uses the nematode C. elegans to investigate the conserved processes that control cell migration and mechanosensation in vivo. Teaching Activities: To become a successful scientist, the student must understand the fundamentals of the discipline, think critically and creatively, and communicate effectively. My goal is to help students learn theory and content in my Genetics, Molecular Biology, and Molecular Cell Biology classes and to practice what they have learned in research experiences in my lab.
Structural and functional evaluation of C. elegans filamins FLN-1 and FLN-2 (with Christina R. DeMaso, Ismar Kovacevic, and Alper Uzun), Biology Faculty Publications (2011)
Filamins are long, flexible, multi-domain proteins composed of an N-terminal actin-binding domain (ABD) followed by...