Past studies have indicated strong family bonds may act to buffer against adolescent substance abuse. However, this relationship is not clear, particularly when multiple substances and family dysfunction are examined. In this study, the relationship between alcohol use, marijuana use, and tobacco use and parental relationships were examined in 570 elementary and high school students. Results indicated that support in parent–child relationships was found to be inversely correlated with teen substance use. Clinical implications are discussed in light of these results.