We investigated factors that may relate to positive outcomes in a web-based introductory nutrition course: age, gender, prior nutrition knowledge, nutrition attitude, attitude toward technology, satisfaction with the instructor, and satisfaction with peer interaction. Fifty-four students completed pre-post surveys of knowledge, altitudes, and course satisfaction. When adjusted for multiple variables, satisfaction with the instructor and prior nutrition knowledge related to achievement in nutrition knowledge from pre- to posttest. Age, satisfaction with the instructor, and prior nutrition knowledge predicted course grade. Satisfaction with the instructor and satisfaction with peer interaction related to self-reported learning. Satisfaction with peer interaction, satisfaction with the instructor, and attitude toward technology predicted course satisfaction. Satisfaction with the instructor and age related to a student's willingness to improve nutrition behavior. Satisfaction with the instructor predicted a student's perceived increase in computer competence. Findings provide evidence that student interaction with instructors and peers has important implications for success and satisfaction in online learning.