As incidence of chronic hepatitis C (CHC) in the United States increases, management of physical and psychological symptoms over the long term becomes crucial. Research has shown meditation to be a valuable tool in reducing such symptoms for various chronic illnesses. In particular, the Mindfulness-Based Stress Reduction (MBSR) program offers curriculum that has been show to influence both physiology and perception of disease states. Although there has been not direct research to date on the effectiveness of the MBSR program for CHC, several studies have shown significant findings affecting other chronic conditions including heart disease, fibromyalgia and HIV. The purpose of this literature review is to examine recent research, summarize findings and indicate appropriate inclusion of MBSR as a primary, secondary and tertiary treatment option in conjunction with biomedical care for those diagnosed with CHC.