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Influenza A (H1N1) Virus Resistance to Cyanovirin-N Arises Naturally during Adaptation to Mice and by Passage in Cell Culture in the Presence of the Inhibitor (with M. K. Wandersee, M. B. Checketts, B. R. O'Keefe, C. Saucedo, M. R. Boyd, V. P. Mishin, and L. V. Gubareva), Antiviral Chemistry and Chemotherapy (2008)
Influenza A/New Caledonia/20/99 (H1N1) virus was studied for development of resistance to cyanovirin-N (CVN). CVN...
Treatment of Venezuelan Equine Encephalitis Virus Infection with (-)-Carbodine (with Justin G. Julander, R. A. Bowen, J. Rao, C. D. Day, K. Shafer, John D. Morrey, and C. K. Chu), Antiviral Research (2008)
Venezuelan equine encephalitis virus (VEEV) may cause encephalitis in humans, for which no FDA-approved antiviral...
Cell Line Dependency for Antiviral Activity and in Vivo Efficacy of N-Methanocarbathymidine against Orthopoxvirus Infections in Mice (with M. K. Wanderee, K. W. Bailey, M-H. Wong, C. K. Chu, S. Gadthula, and R. W. Sidwell), Antiviral Research (2007)
A novel carbocyclic thymidine analog, N-methanocarbathymidine [(N)-MCT], was evaluated for inhibition of orthopoxvirus infections. Efficacy...
Correlation between Breakdown of the Blood-brain Barrier and Disease Outcome of Viral Encepthalitis in Mice (with Aaron L. Olsen, John D. Morrey, and R. W. Sidwell), Antiviral Research (2007)
Changes in the permeability of the blood–brain barrier (BBB) were evaluated in two mouse models...
Differential Pathogenesis of Cowpox Virus Intranasal Infections in Mice Induced by Low and High Inoculum Volumes and Effects of Cidofovir Treatment (with Brian B. Gowen, M. K. Wandersee, M-H. Wong, Ramona T. Skirpstunas, Thomas J. Baldwin, J. D. Hoopes, and R. W. Sidwell), International Journal of Antimicrobial Agents (2007)
The causes of death from intranasal cowpox virus infections in mice remain unclear. Hypotheses include...
Efficacy of N-Methanocarbathymidine in Treating Mice Infected Intranasally with the IHD and WR Strains of Vaccinia Virus (with B. L. Hurst, M-H. Wong, R. I. Glazer, A. Rahman, and R. W. Sidwell), Antiviral Research (2007)
N-Methanocarbathymidine [(N)-MCT] is a newly identified inhibitor of orthopoxvirus replication in cell culture and in...
Efficacy of Orally Administered T-705 on Lethal Avian Influenza A (H5N1) Virus Infections in Mice (with R. W. Sidwell, Dale L. Barnard, C. W. Day, K. W. Bailey, M. H. Wong, John D. Morrey, and Y. Furuta), Antimicrobial Agents and Chemotherapy (2007)
T-705 (6-fluoro-3-hydroxy-2-pyrazinecarboxamide) was inhibitory to four strains of avian H5N1 influenza virus in MDCK cells,...
Identification of Novel Antipoxviral Agents: Mitoxantrone Inhibits Vaccinia Virus Replication by Blocking Virion Assembly (with L. Deng, P. Dai, A. Ciro, H. Djaballah, and S. Schuman), Journal of Virology (2007)
The bioterror threat of a smallpox outbreak in an unvaccinated population has mobilized efforts to...
Neutralizing Viruses in Suspensions by Copper Oxide-Based Filters (with G. Borkow, R. W. Sidwell, Dale L. Barnard, John D. Morrey, H. H. Lara-Villegas, Y. Shemer-Avni, and J. Gabbay), Antimicrobial Agents and Chemotherapy (2007)
We report the capacity of copper oxide-containing filters to reduce infectious titers of a panel...
Novel 3-Sulphonamido-Quinazolin-4(3H)-One Derivatives: Microwave-Assisted Synthesis and Evaluation of Antiviral Activities against Respiratory and Biodefense Viruses (with P. Selvam, P. Vijayalakshimi, Brian B. Gowen, Justin G. Julander, C. W. Day, and Dale L. Barnard), Antiviral Chemistry and Chemotherapy (2007)
We designed and synthesized novel 2,3-disubstituted quinazolin-4(3H)-ones by microwave technique and characterized them by spectral...
Activities of Oseltamivir and Ribavirin Used Alone and in Combination against Infections in Mice with Recent Isolates of Influenza A (H1N1) and B Viruses (with M.-H. Wong, K. W. Bailey, and R. W. Sidwell), Antiviral Chemistry and Chemotherapy (2006)
Mouse models have been widely used for evaluating potential influenza virus inhibitors. However, the viral...
Anti-Influenza Virus Activities of 4-[(1,2-Dihydro-2-Oxo-3H-Indol-3-Ylidene)Amino]-N-(4,6-Dimethyl-2-Pyrimidin-2-yl)Benzenesulphonamide and its Derivatives (with P. Selvam, N. Murugesh, M. Chandramohan, R. W. Sidwell, and M. K. Wandersee), Antiviral Chemistry and Chemotherapy (2006)
4-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)amino]-N-(4,6-dimethyl-2-pyrimidinyl)-benzenesulphonamide (SPIII-5H) and related compounds were tested for antiviral activity against influenza A (H1N1, H3N2,...
Combinatorial Ribavirin and Interferon Alfacon-1 Therapy of Acute Arenaviral Disease in Hamsters (with Brian B. Gowen, M. Wong, A. M. Pace, K. Jung, K. W. Bailey, L. M. Blatt, and R. W. Sidwell), Antiviral Chemistry and Chemotherapy (2006)
Several arenaviruses endemic to South America (Junin, Machupo, and Guanarito) and Africa (Lassa) are known...
Development of Antiviral Drugs against Avian (H5N1) Influenza Virus (with R. W. Sidwell and Dale L. Barnard), Recent Developments on the Avian Influenza (H5N1) Crisis (2006)
The avian influenza H5N1 virus first emerged in 1997 when it infected 18 people and...
Effect of Cidofovir Treatment on Cytokine Induction in Murine Models of Cowpox and Vaccinia Virus Infection (with C. W. Knorr, S. D. Allen, and A. R. Torres), Antiviral Research (2006)
Cytokine profiles during cowpox and vaccinia (WR strain) virus infections were characterized in intranasal (i.n.)...
Mutations in Influenza Virus M1 CCHH, the Putative Zinc Finger Motif, Cause Attenuation in Mice and Protect Mice against Lethal Influenza Virus Infection (with E. K.-W. Hui, M-H. Wong, and D. P. Nayak), Journal of Virology (2006)
Mutations in CCHH, the putative zinc finger motif, apparently do not play an important role...
Mutations in the E9L Polymerase Gene of Cidofovir-Resistant Vaccinia Virus Strain WR Are Associated with the Drug Resistance Phenotype (with R. S. Kornbluth, R. W. Sidwell, V. Snarsky, D. H. Evans, and K. Y. Hostetler), Antimicrobial Agents and Chemotherapy (2006)
Cidofovir (CDV) is an effective drug against viruses of the Orthopoxviridae family and is active...
Protective Immunity against Acute Phleboviral Infection Elicited through Immunostimulatory Cationic Liposome-DNA Complexes (with Brian B. Gowen and J. Fairman), Antiviral Research (2006)
Cationic liposome-DNA complexes (CLDC) have been demonstrated to induce potent antitumor activities. The ability of...
Recombinant Eimeria Protozoan Protein Elicits Resistance to Acute Phlebovirus Infection in Mice but Not Hamsters (with Brian B. Gowen, M. Wong, J. W. Judge, K. Jung, K. W. Bailey, A. M. Pace, B. Rosenberg, and R. W. Sidwell), Antimicrobial Agents and Chemotherotherapy (2006)
A protein antigen from an Eimeria protozoan has recently been reported to induce antitumor activity...
Sialidase Fusion Protein as a Novel Broad-Spectrum Inhibitor of Influenza Virus Infection (with M. P. Malakhov, L. M. Aschenbrenner, M. K. Wandersee, R. W. Sidwell, L. V. Gubareva, V. P. Mishin, F. G. Hayden, D. H. Kim, A. Ing, E. R. Campbell, M. Yu, and F. Fang), Antimicrobial Agents and Chemotherapy (2006)
Influenza is a highly infectious disease characterized by recurrent annual epidemics and unpredictable major worldwide...
Broad-Spectrum Inhibitor of Viruses in the Flaviviridae Family (with J. O. Ojwang, S. Ali, John D. Morrey, C. D. Shimasaki, and R. W. Sidwell), Antiviral Research (2005)
The viruses in the Flaviviridae family have been associated with human and animal diseases. In...
Characterization and Treatment of Cidofovir-Resistant Vaccinia (WR Strain) Virus Infections in Cell Culture and in Mice (with M. K. Wandersee, K. W. Bailey, K. Y. Hostetler, A. Holy, and R. W. Sidwell), Antiviral Chemistry and Chemotherapy (2005)
The wild-type (WT) vaccinia (WR strain) virus is highly virulent to mice by intranasal inoculation,...
Error-Prone Replication of West Nile Virus Caused by Ribavirin (with C. W. Day, Justin G. Julander, V. F. Yamshchikov, R. W. Sidwell, and John D. Morrey), Antiviral Research (2005)
Ribavirin has been reported to cause error-prone replication and viral extinction in RNA viruses. The...
Interferon Alfacon-1 Protects Hamsters from Lethal Pichinde Virus Infection (with Brian B. Gowen, Dale L. Barnard, M. H. Wong, A. M. Pace, K. H. Jung, S. G. Winslow, K. W. Bailey, L. M. Blatt, and R. W. Sidwell), Antimicrobial Agents and Chemotherotherapy (2005)
Hemorrhagic fever of arenaviral origin is a frequently fatal infectious disease of considerable priority to...
In Vitro and in Vivo Influenza Virus-Inhibitory Effects of Viramidine (with R. W. Sidwell, K. W. Bailey, M-H. Wong, and Dale L. Barnard), Antiviral Research (2005)
Viramidine, the 3-carboxamidine derivative of ribavirin, was effective against a spectrum of influenza A (H1N1,...
Anti-Cowpox Virus Activities of Certain Adenosine Analogs, Arabinofuranosyl Nucleosides, and 2′-Fluoro-Arabinofuranosyl Nucleosides (with R. W. Sidwell), Nucleosides, Nucleotides and Nucleic Acids (2004)
Nucleoside analogs were investigated for their potential to inhibit cowpox virus (a surrogate for variola...
Effect of Interferon-Alpha and Interferon- Inducers on West Nile Virus in Mouse and Hamster Animal Models (with John D. Morrey, C. W. Day, Justin G. Julander, L. M. Blatt, and R. W. Sidwell), Antiviral Chemistry and Chemotherapy (2004)
The recent West Nile virus (WNV) outbreak in the United States has increased the need...
Effects of Four Antiviral Substances on Lethal Vaccinia Virus (IHD Strain) Respiratory Infections in Mice (with M-H. Wong, K. W. Bailey, J. R. Beadle, K. Y. Hostetler, and R. W. Sidwell), International Journal of Antimicrobial Agents (2004)
Intranasal infection of BALB/c mice with the IHD strain of vaccinia virus was found to...
Experimental Disease Models of Influenza Virus Infections: Recent Developments (with R. W. Sidwell), Drug Discovery Today: Disease Models (2004)
Influenza continues to be an important public health threat, and a need continues for models...
Inhibition of Severe Acute Respiratory Syndrome-Associated Coronavirus (SARSCoV) by Calpain Inhibitors and Beta-D-N4-Hydroxycytidine (with Dale L. Barnard, V. D. Hubbard, J. Burton, John D. Morrey, M. Otto, and R. W. Sidwell), Antiviral Chemistry and Chemotherapy (2004)
We evaluated two types of compounds for efficacy in inhibiting SARSCoV replication in vitro: calpain...
In Vitro Activity of Expanded-Spectrum Pyridazinyl Oxime Ethers Related to Pirodavir: Novel Capsid-Binding Inhibitors with Potent Antipicornavirus Activity (with Dale L. Barnard, V. D. Hubbard, R. W. Sidwell, K.G. W. Watson, S.P. T. Tucker, and P.A. R. Reece), Antimicrobial Agents and Chemotherapy (2004)
Picornaviruses (PV) include human rhinovirus (HRV), the primary cause of the common cold, and the...
Topical Cidofovir Is More Effective than Is Parenteral Therapy for Treatment of Progressive Vaccinia in Immunocompromised Mice (with K. W. Bailey, M-H. Wong, M. K. Wandersee, and R. W. Sidwell), The Journal of Infectious Diseases (2004)
Background.Severe complications may arise as a result of virus dissemination after smallpox (live vaccinia virus)...
Treatment of Mannan-Enhanced Influenza B Virus Infections in Mice with Oseltamivir, Ribavirin and Viramidine (with M. K. Wandersee, M-H. Wong, K. W. Bailey, and R. W. Sidwell), Antiviral Chemistry and Chemotherapy (2004)
Mannan, a polysaccharide preparation from Saccharomyces cerevisiae, has previously been shown to enhance influenza virus...
A Review of Compounds Exhibiting Anti-Orthopoxvirus Activity in Animal Models (with R. W. Sidwell), Antiviral Research (2003)
Several animal models using mice (most frequently), rabbits, or monkeys have been used to identify...
Comparative Effects of Cidofovir and Cyclic HPMPC on Lethal Cowpox and Vaccinia Virus Respiratory Infections in Mice (with K. W. Bailey and R. W. Sidwell), Chemotherapy (2003)
Cidofovir is approved for the treatment of cytomegalovirus retinitis in humans. Although highly effective, the...
Inhibition of Influenza Virus Infections in Immunosuppressed Mice with Orally Administered Peramivir (BCX-1812) (with R. W. Sidwell, K. W. Bailey, John D. Morrey, M. H. Wong, and Thomas J. Baldwin), Antiviral Research (2003)
Experiments were run to determine the effect of oral gavage treatment with the cyclopentane influenza...
Potent Anti-Influenza Activity of Cyanovirin-N and Interactions with Viral Hemagglutinin (with B. R. O'Keefe, J. A. Turpin, C. J. Saucedo, K. R. Gustafson, T. Mori, D. Blakeslee, R. Buckheit, and M. R. Boyd), Antimicrobial Agents and Chemotherapy (2003)
The novel antiviral protein cyanovirin-N (CV-N) was initially discovered based on its potent activity against...
Viruses of the Bunya- and Togaviridae Families: Potential as Bioterrorism Agents and Means of Control (with R. W. Sidwell), Antiviral Research (2003)
When considering viruses of potential importance as tools for bioterrorism, several viruses in the Bunya-...