This paper proposes a taxonomy of business models used by small, highly innovative firms focused on technology commercialization that disproportionately contribute to technological change in the US economy. The firms operate across industries and use a variety of technology platforms. Exploratory factor analysis of keyword occurrence on firm websites generated a taxonomy comprising: research organization; development stage biosciences; highly specialized component supplier; specialized subcontractor; product solutions providers; and service solutions providers. This framework provides entrepreneurs and policy makers with an overview of new technology commercialization paths tailored to small, innovative firms.