The effect of epidural xylazine on halothane minimum alveolar concentration in ponies
The effects of epidurally administered xylazine on halothane minimum alveolar concentration (MAC) were examined in 6 healthy pony geldings. Anaesthesia was induced with i.v. administration of thiopentone (4 mg/kg) and succinylcholine (0.15 mg/kg) and maintained with halothane in oxygen. Following baseline halothane MAC determination, each pony was given 0.15 mg/kg xylazine hydrochloride or saline epidurally. No change in halothane MAC was observed following saline administration. Xylazine administration, however, significantly decreased halothane MAC from 0.93 to 0.61% in the thoracic limb and from 0.93 to 0.53% in the pelvic limb. Recovery from anaesthesia was uneventful and no adverse effect was observed. It is concluded that epidural xylazine has significant antinociceptive effect in ponies.
Thomas J. Doherty, Dennis R. Geiser, and Barton W. Rohrbach Dr.. "The effect of epidural xylazine on halothane minimum alveolar concentration in ponies" Journal of Veterinary Pharmacology and Therapeutics 20.3 (1997): 246-248.
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