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Electrostatic Interactions Affect Nanoparticle-Mediated Toxicity to Gram-Negative Bacterium Pseudomonas aeruginosa PAO1

Kevin Feris, Boise State University
Caitlin Otto, Boise State University
Juliette Tinker, Boise State University
Denise Wingett, Boise State University
Alex Punnoose, Boise State University
Aaron Thurber, Boise State University
Madhu Kongara, Boise State University
Maryam Sabetian, Boise State University
Bonnie Quinn, St. Francis Xavier University
Charles Hanna, Boise State University
David Pink, St. Francis Xavier University

Article comments

Langmuir, Volume 26, Issue 6, 4429-4436. DOI: 10.1021/la903491z

Abstract

Nanoscale materials can have cytotoxic effects. Here we present the first combined empirical and theoretical investigation of the influence of electrostatic attraction on nanoparticle cytotoxicity. Modeling electrostatic interactions between cells and 13 nm spheres of zinc oxide nanoparticles provided insight into empirically determined variations of the minimum inhibitory concentrations between four differently charged isogenic strains of Pseudomonas aeruginosa PAO1. We conclude that controlling the electrostatic attraction between nanoparticles and their cellular targets may permit the modulation of nanoparticle cytotoxicity.

Suggested Citation

Kevin Feris, Caitlin Otto, Juliette Tinker, Denise Wingett, Alex Punnoose, Aaron Thurber, Madhu Kongara, Maryam Sabetian, Bonnie Quinn, Charles Hanna, and David Pink. "Electrostatic Interactions Affect Nanoparticle-Mediated Toxicity to Gram-Negative Bacterium Pseudomonas aeruginosa PAO1" Langmuir 26.6 (2009): 4429-4436.
Available at: http://works.bepress.com/denise_wingett/14