Professor Of Neuroscience, Physiology, and Pharmacology, Dept. of Biomedical Sciences
Dr. Appelt is a professor of Neuroscience in the department of Bio-Medical Sciences. She has served as the director for Basic and Clinical Neuroscience course in the DO curriculum and the director of the Neuroscience course in the Biomedical master program. Dr. Appelt lectures on neuroanatomy and participates in neuroanatomy labs in the DO SPOM course, Physician Assistant Studies, and Psychology program. In addition, Dr. Appelt is the director for the dual degree DO/PhD. program in Cellular and Molecular Biology designed to develop physician-scientist.
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About Denah Appelt
Dr. Appelt is a professor of Neuroscience in the department of Bio-Medical Sciences. She has served as the director for Basic and Clinical Neuroscience course in the DO curriculum and the director of the Neuroscience course in the Biomedical master program. Dr. Appelt lectures on neuroanatomy and participates in neuroanatomy labs in the DO SPOM course, Physician Assistant Studies, and Psychology program. In addition, Dr. Appelt is the director for the dual degree DO/PhD. program in Cellular and Molecular Biology designed to develop physician-scientist.
| Present | Professor Of Neuroscience, Dept. of Biomedical Sciences, Philadelphia College of Osteopathic Medicine ‐ Department of Bio-Medical Sciences | |
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| Present | Program Director, Dual DO/PhD. Biomedical Science Specialty Concentrations in the School of Health Sciences, Philadelphia College of Osteopathic Medicine ‐ Department of Bio-Medical Sciences | |
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| Director, Biological Imaging Facility, Philadelphia College of Osteopathic Medicine | ||
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| Researcher, Center for Chronic Diseases of Aging, Philadelphia College of Osteopathic Medicine | ||
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Disciplines
Research Interests
Grants
| 2003 - Present | Chlamydia pneumoniae’s role in the pathogenesis of sporadic Alzheimer’s disease |
| Rose and Adolf Levis Foundation | |
| Role: Co-PI | |
| 2013 - 2014 | Bactericidal Implant Surfaces |
| CCDA | |
| Role: Co-PI | |
| 2012 - 2013 | Detection of Chlamydia pneumoniae in blood samples: A diagnostic screen for Alzheimer’s disease |
| CCDA | |
| Role: Co-PI | |
| 2012 - 2013 | Infection with Chlamydia Pneumoniae alters calcium-associated gene regulations and processes in neuronal cells and monocytes: Implications for Alzheimer’s disease |
| CCDA | |
| Role: Co-PI | |
| 2009 - 2013 | Dissecting the apoptosis pathway affected by C. pneumoniae in Alzheimer's disease |
| Health Research Formula Fund | |
| Role: PI | |
| 2011 - 2012 | Analysis by Real-Time PCR of Autophagy and Apoptosis in Neuronal Cells Infected with Chlamydia Pneumoniae |
| CCDA | |
| Role: PI | |
| 2008 - 2009 | Chlamydophila (Chlamydia) pneumoniae (Cpn) promotes Aβ 1-42 amyloid processing in Neuronal Cells: A Pathogenic Trigger for Alzheimer’s disease |
| CCDA | |
| Role: PI | |
| 2007 - 2008 | Effects on the apoptotic markers following a Chlamydial infection in neurons and astrocytes: Implications for Alzheimer’s disease |
| CCDA | |
| Role: PI | |
| 2003 - 2008 | Mechanisms of Cadmium Toxicity in Epithelial Cells |
| NIH - R01ES006478-09A2 | |
| Role: Collaborator | |
| 2004 - 2007 | Chlamydia pneumoniae infection of Mice triggers Alzheimer-like pathology |
| Alzheimer Association | |
| Role: Co-Investigator | |
| 1999 - 2004 | Chlamydia pneumoniae: a pathogen in Alzheimer’s disease? |
| NIH/NIAID - R01 AI44055-01A1 | |
| Role: Co-Investigator | |
| 2001 - 2003 | Immunosenescence and Chlamydia Pneumoniae |
| NIH/R15 | |
| Role: Co-Investigator | |
| 1999 - 2003 | Investigation of Chlamydia pneumoniae in Diseases of the Aging |
| Foundation for Research into the Diseases of Aging | |
| Role: Co-Investigator | |
| 1999 - 2000 | Pathologic manifestations induced by Chlamydia Pneumonia infected glial cells in AD |
| National Foundation for Infectious Diseases | |
| Role: PI |
Professional Service and Affiliations
| 2013 - Present | Member, PCOM Presidential Diversity Council | 2013 - Present | Member, PCOM Research Committee | 1999 - Present | Member, PCOM D.O. Admissions Committee | 2014 - 2015 | Chair, PCOM Faculty Senate | 2012 - 2014 | Section Chair, Middle States Accreditation Self-Study Committee | 2012 - 2013 | Member, PCOM Faculty Search Committee | 2010 - 2013 | Member, PCOM Honors and Awards committee | 2009 - 2013 | Vice Chair, PCOM Institutional and Environmental Health and Safety Committee | 2011 - 2012 | Member, PCOM Chief Science Officer Search Committee | 2009 - 2010 | Member, PCOM Faculty Representative to Executive Faculty | 2003 - 2009 | Member, PCOM Appointment, Promotion and Tenure Committee | 2007 - 2008 | Secretary, PCOM Faculty Senate | 2004 - 2004 | Organizer, PCOM Symposium Challenging Views of Alzheimer’s Disease |
Honors and Awards
- 2013 Lindback Distinguished Teaching Award
- 2008 PCOM Teacher of the Year
- 2003 Kappa SIgma Phi Award for Osteopathic Education
- 1996 American Society for Cell Biology-Glenn Foundation Award for Outstanding Research in Aging
| PhD, Drexel University College of Medicine | ||
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| BS, Juniata College | ||
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Links
Contact Information
p: 215-871-6164
Email:
