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Cytotoxic clerodane diterpenes from Glossocarya calcicola

Heidi L. Rasikari, Southern Cross University
David N. Leach, Southern Cross University
Peter G. Waterman, Southern Cross University
Robert N. Spooner-Hart, University of Western Sydney
Albert H. Basta, University of Western Sydney
Linda K. Banbury, Southern Cross University
Kelly M. Winter, Southern Cross University
Paul I. Forster, Brisbane Botanic Gardens

Abstract

Three clerodane diterpenes were isolated and identified from leaf extract of Glossocarya calcicola. Compound 1 has been characterised as (rel)-10âH-trans-12î-(2-methylbut-2(E)-enoyl)-1â-(isobutanoyl)-6á,13î-dihydroxyclerodan-4(20),8(18)-dien-7,15-dione-15,16-oxide, to which we have assigned the trivial name calcicolin-A. The other two compounds had the same skeletal structure and C-12 substituent but in compound 2, the C-1 esterifying group becomes 2-methylbut-2(E)-enoic acid and in 3 it becomes 2-methylbutanoic acid. Although anti-insect activity was not observed for G. calcicola, cytotoxicity against insect and human carcinoma cell lines was detected.

Suggested Citation

Rasikari, HL, Leach, DN, Waterman, PG, Spooner-Hart, RN, Basta, AH, Banbury, LK, Winter, KM & Forster, PI 2005, 'Cytotoxic clerodane diterpenes from Glossocarya calcicola', Phytochemistry, vol. 66, no. 24, pp. 2844-2850.

Phytochemistry journal home page available at http://www.elsevier.com/wps/product/cws_home/273

Publisher's version of article available at http://dx.doi.org/10.1016/j.phytochem.2005.09.024