Inhibitory effects of 12 hemostatic Chinese herbs on nitric oxide production in LPS-activated RAW264.7 macrophages
To investigate the inhibitory effects of 12 hemostatic Chinese herbs on Nitric Oxide production in lipopolysaccharide(LPS)activated RAW 264.7 Macrophages. METHODS:
Nitric Oxide production was determined with Griess assay after 22 hrs stimulation of 1 μ g· mL-1 LPS on RAW 264.7.Nitrite concentrations were determined by comparison with a sodium nitrite standard curve.
The markedly increased production of nitrite by stimulation of RAW 264.7 macrophages with LPS was inhibited significantly(P0.05)by:Panax Notoginseng,Sanguisorba Officinalis,Agrimonia Pilosa,Sophora Japonica,Artemisia Argyi,Typha Angustifolia,Platycladus Orientalis and Imperata Cylindrical.
The hemostatic action of 12 herbs may be related to their inhibitory effect on Nitric Oxide production
Liao, H, Banbury, LK & Leach, DN 2007, 'Inhibitory effects of 12 hemostatic Chinese herbs on nitric oxide production in LPS-activated RAW264.7 macrophages', Journal of China Pharmacy, vol. 18, no. 9, pp. 117-130.
The publisher's version of this article is available at http://dx.doi.org/CNKI:SUN:ZGYA.0.2007-09-005
Linda Banbury has also published under the name of Linda McClure
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