Article
Susceptibility of Chlamydia trachomatis to the excipient hydroxy-ethylcellulose: pH and concentration dependence of antimicrobial activity
Antimicrobial Agents and Chemotherapy
ORCiD
David M. Ojcius: 0000-0003-1461-4495
Department
Biomedical Sciences
Document Type
Article
DOI
10.1128/AAC.00785-07
Publication Date
4-14-2008
Disciplines
Abstract
Hydroxyethyl cellulose (HEC) is used as a neutral excipient in microbicides used against sexually transmitted pathogens. However, HEC inhibits the infection of cervical epithelial cells by Chlamydia trachomatis at pH 5 in a concentration-dependent manner. At pH 7, infection is inversely dependent on the concentration of HEC, possibly due to pH-dependent calcium sequestration.
Citation Information
Ali A. Abdul-Sater, David M. Ojcius and M. P. Meyer. "Susceptibility of Chlamydia trachomatis to the excipient hydroxy-ethylcellulose: pH and concentration dependence of antimicrobial activity" Antimicrobial Agents and Chemotherapy Vol. 52 Iss. 7 (2008) p. 2660 - 2662 ISSN: 0066-4804 Available at: http://works.bepress.com/david-ojcius/216/