Article
Azaadamantane Benzamide 5-HT4 Agonists: Gastrointestinal Prokinetic SC-54750
Bioorganic & Medicinal Chemistry Letters
Document Type
Article
Publication Date
11-15-2004
Pages
5509-5512
Publisher Name
Elsevier
Disciplines
Abstract
Azaadamantanone 1 was converted to a series of aminoazaadamantane benzamides 9a–d, which were profiled for serotonin receptor activity. Aminomethylazaadamantane SC-54750 is a potent 5-HT4 agonist and 5-HT3 antagonist with in vivo efficacy in gastroparesis models and also inhibits cisplatin-induced emesis.
Comments
Author Posting © Elsevier, 2004. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution. The definitive version was published in Bioorganic & Medicinal Chemistry Letters, Volume 14, Issue 22, November 15, 2004. http://dx.doi.org/10.1016/j.bmcl.2004.09.005
Creative Commons License
Creative Commons Attribution-Noncommercial-No Derivative Works 3.0
Copyright Statement
© 2004 Elsevier
Citation Information
Daniel Becker, Daniel L. Flynn, Robert L. Shone and Gary Gullikson. "Azaadamantane Benzamide 5-HT4 Agonists: Gastrointestinal Prokinetic SC-54750" Bioorganic & Medicinal Chemistry Letters Vol. 14 Iss. 22 (2004) Available at: http://works.bepress.com/daniel_p_becker/8/