Article
1,3,4-Trisubstituted Pyrrolidinones as Scaffolds for Construction of Peptidomimetic Cholecystokinin Antagonists
Bioorganic & Medicinal Chemistry Letters
Document Type
Article
Publication Date
10-1-1992
Pages
1251-1256
Publisher Name
Elsevier
Disciplines
Abstract
A new series of cholecystokinin (CCK) antagonists are described which utilizes a new 1,3,4-trisubstituted pyrrolidinone as a scaffold for appending specific amino acid R group mimics (Figure 1). Compound 1A and 1E (SC-50998) exhibit potent nanomolar IC50 values in a CCK-A receptor binding assay. Compound 1E behaves as a competitive antagonist in vitro and is orally active.
Comments
Author Posting © Elsevier, 1992. The definitive version was published in Bioorganic & Medicinal Chemistry Letters, Volume 2, Issue 10, October 1992. http://dx.doi.org/10.1016/S0960-894X(00)80224-3
Creative Commons License
Creative Commons Attribution-Noncommercial-No Derivative Works 3.0
Copyright Statement
© 1992 Elsevier
Citation Information
Daniel L. Flynn, Clara I. Villamil, Daniel Becker and Gary W. Gullikson. "1,3,4-Trisubstituted Pyrrolidinones as Scaffolds for Construction of Peptidomimetic Cholecystokinin Antagonists" Bioorganic & Medicinal Chemistry Letters Vol. 2 Iss. 10 (1992) Available at: http://works.bepress.com/daniel_p_becker/4/