Article
New (Nor)Aza-Adamantanes Are Agonists at the Newly Identified Serotonin 5HT4 Receptor and Antagonists at the 5HT3 Receptor
Bioorganic & Medicinal Chemistry Letters
Document Type
Article
Publication Date
12-1-1992
Pages
1613-1618
Publisher Name
Elsevier
Disciplines
Abstract
New aza(nor)adamantanes 1A, 1B, and 1C are described which exhibit properties of both 5-HT4 agonism and 5-HT3 antagonism. In particular, compound 1C [SC-52491], an azanoradamantane, exhibits an EC50 of 51 nM in a functional model of 5-HT4 agonism and potent antagonism, Ki = 1.2 nM, at the 5-HT3receptor.
Creative Commons License
Creative Commons Attribution-Noncommercial-No Derivative Works 3.0
Copyright Statement
© 1992 Elsevier
Citation Information
Daniel L. Flynn, Daniel Becker, Dale P. Spangler and Roger Nosal. "New (Nor)Aza-Adamantanes Are Agonists at the Newly Identified Serotonin 5HT4 Receptor and Antagonists at the 5HT3 Receptor" Bioorganic & Medicinal Chemistry Letters Vol. 2 Iss. 12 (1992) Available at: http://works.bepress.com/daniel_p_becker/30/
Author Posting © Elsevier, 1992. The definitive version was published in Bioorganic & Medicinal Chemistry Letters, Volume 2, Issue 12, December 1992. http://dx.doi.org/10.1016/S0960-894X(00)80441-2