Article
Orally Bioavailable Dual MMP-1/MMP-14 Sparing, MMP-13 Selective Alpha-sulfone Hydroxamates
Bioorganic & Medicinal Chemistry Letters
Document Type
Article
Publication Date
6-15-2010
Pages
3557-3560
Publisher Name
Elsevier
Disciplines
Abstract
A series of phenyl piperidine α-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13, are dual-sparing of MMP-1 and MMP-14 (MT1-MMP) and exhibit oral bioavailability in rats.
Creative Commons License
Creative Commons Attribution-Noncommercial-No Derivative Works 3.0
Copyright Statement
© 2010 Elsevier
Citation Information
Daniel Becker, Stephen A. Kolodziej, Susan L. Hockerman, Terri L. Boehm, et al.. "Orally Bioavailable Dual MMP-1/MMP-14 Sparing, MMP-13 Selective Alpha-sulfone Hydroxamates" Bioorganic & Medicinal Chemistry Letters Vol. 20 Iss. 12 (2010) Available at: http://works.bepress.com/daniel_p_becker/27/
Author Posting © Elsevier, 2010. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution. The definitive version was published in Bioorganic & Medicinal Chemistry Letters , Volume 20, Issue 12, June 15, 2010. http://dx.doi.org/10.1016/j.bmcl.2010.04.130