Article
Bridgehead-methyl Analog of SC-53116 as a 5-HT4 Agonist
Bioorganic & Medicinal Chemistry Letters
Document Type
Article
Publication Date
6-21-2004
Pages
3073-3075
Publisher Name
Elsevier
Disciplines
Abstract
Pyrrolizidine benzamide (±)-2, the bridgehead-methyl analog of SC-53116, was prepared and evaluated for 5-HT4 agonism activity in the rat tunica muscularis (TMM) mucosae assay. Compound (±)-2 has an EC50 of 449 nM in the TMM assay, as compared to 23 nM for SC-53116, and 66 nM for the racemate of SC-53116.
Creative Commons License
Creative Commons Attribution-Noncommercial-No Derivative Works 3.0
Copyright Statement
© 2004 Elsevier
Citation Information
Daniel Becker, Daniel L. Flynn and Clara I. Villamil. "Bridgehead-methyl Analog of SC-53116 as a 5-HT4 Agonist" Bioorganic & Medicinal Chemistry Letters Vol. 14 Iss. 12 (2004) Available at: http://works.bepress.com/daniel_p_becker/24/
Author Posting © Elsevier, 2004. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution. The definitive version was published in Bioorganic & Medicinal Chemistry Letters, Volume 14, Issue 12, June 21, 2004. http://dx.doi.org/10.1016/j.bmcl.2004.04.021