Article
Asymmetric α-hydroxy Ketone Synthesis by Direct Ketone Oxidation Using a Bimetallic Palladium(II) Complex
Tetrahedron Letters
Document Type
Article
Publication Date
5-30-2012
Pages
2699-2701
Publisher Name
Elsevier
Disciplines
Abstract
The oxidation of ketones by a chiral bimetallic palladium(II) complex in the presence of CuCl2 in THF–water solvents gave an enantioselective synthesis of α-hydroxyketones in catalytic oxidation utilizing an atmosphere of oxygen. The ee’s ranged from 61% to 92%. The reaction was accelerated by addition of strong acid that presumably increases the rate of enolization.
Creative Commons License
Creative Commons Attribution-Noncommercial-No Derivative Works 3.0
Copyright Statement
© 2012 Elsevier
Citation Information
Othman A. Hamed, Arab El-Qisairi, Hanan Qaseer, Emad M. Hamed, et al.. "Asymmetric α-hydroxy Ketone Synthesis by Direct Ketone Oxidation Using a Bimetallic Palladium(II) Complex" Tetrahedron Letters Vol. 53 Iss. 22 (2012) Available at: http://works.bepress.com/daniel_p_becker/21/
Author Posting © Elsevier, 2012. This article is posted here by permission of Elsevier for personal use, not for redistribution. The definitive version was published in Tetrahedron Letters, Volume 53, Issue 22, May 30, 2012. http://dx.doi.org/10.1016/j.tetlet.2012.03.066