Article
Alpha-Alkyl-alpha-amino-beta-sulphone Hydroxamates as Potent MMP Inhibitors that Spare MMP-1
Bioorganic & Medicinal Chemistry Letters
Document Type
Article
Publication Date
10-22-2001
Pages
2723-2725
Publisher Name
Elsevier
Disciplines
Abstract
A series of α-alkyl-α-amino-β-sulphone hydroxamates was prepared and evaluated for potency versus MMP-2 and MMP-13, and for selectivity versus MMP-1. Low nanomolar potency was obtained with selectivity versus MMP-1 ranging from >10 to >1000. Selected compounds were orally bioavailable.
Creative Commons License
Creative Commons Attribution-Noncommercial-No Derivative Works 3.0
Copyright Statement
© 2001 Elsevier
Citation Information
Daniel Becker, Gary A. DeCrescenzo, John Freskos and Daniel P. Getman. "Alpha-Alkyl-alpha-amino-beta-sulphone Hydroxamates as Potent MMP Inhibitors that Spare MMP-1" Bioorganic & Medicinal Chemistry Letters Vol. 11 Iss. 20 (2001) Available at: http://works.bepress.com/daniel_p_becker/20/
Author Posting © Elsevier, 2001. This is the author's version of the work. It is posted here by permission of Elsevier for personal use, not for redistribution. The definitive version was published in Bioorganic & Medicinal Chemistry Letters, Volume 11, Issue 20, October 22, 2001. http://dx.doi.org/10.1016/S0960-894X(01)00557-1