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Article
Transgenic Mice Expressing the Intracellular Domain of the p75 Neurotrophin Receptor Undergo Neuronal Apoptosis
The Journal of Neuroscience (1997)
  • M. Majdan, McGill University
  • C. Lachance, McGill University
  • A. Gloster, McGill University
  • R. Aloyz, McGill University
  • C. Zeindler, McGill University
  • S. Bamji, McGill University
  • A. Bhakar, McGill University
  • Daniel Belliveau, The University of Western Ontario
  • J. Fawcett, McGill University
  • F. D. Miller, McGill University
  • P. A. Barker, McGill University
Abstract
We have asked whether p75NTR may play a role in neuronal apoptosis by producing transgenic mice that express the p75NTR intracellular domain within peripheral and central neurons. These animals showed profound reductions in numbers of sympathetic and peripheral sensory neurons as well as cell loss in the neocortex, where there is normally little or no p75NTR expression. Developmental loss of facial motor neurons was not observed, but induced expression of the p75NTR intracellular domain within adult animals led to increased motor neuron death after axotomy. Biochemical analyses suggest that these effects were not attributable to a p75NTR-dependent reduction in trk activation but instead indicate that the p75NTR intracellular domain may act as a constitutive activator of signaling cascades that regulate apoptosis in both peripheral and central neurons.
Keywords
  • nerve growth factor,
  • sympathetic neuron,
  • tumor necrosis factor,
  • cell death,
  • NF-kB,
  • jun kinase
Publication Date
1997
Citation Information
M. Majdan, C. Lachance, A. Gloster, R. Aloyz, et al.. "Transgenic Mice Expressing the Intracellular Domain of the p75 Neurotrophin Receptor Undergo Neuronal Apoptosis" The Journal of Neuroscience Vol. 17 Iss. 18 (1997)
Available at: http://works.bepress.com/daniel_belliveau/11/