Copyright (c) 2009 All rights reserved. http://works.bepress.com/colin_luke Recent documents in Colin Luke en-us Tue, 15 Sep 2009 23:34:06 PDT 3600 http://works.bepress.com/colin_luke/6 http://works.bepress.com/colin_luke/6 Mon, 14 Sep 2009 22:36:02 PDT To evaluate trends in survival and treatment for myeloid leukaemia in South Australia during 1977- 2002, using population-based survival data plus data on survival and treatment of patients at three teaching hospitals. Colin G. Luke http://works.bepress.com/colin_luke/5 http://works.bepress.com/colin_luke/5 Mon, 14 Sep 2009 22:26:11 PDT Treatment guidelines recommend a more conservative surgical approach than mastectomy for early stage breast cancer and a stronger emphasis on adjuvant therapy. Registry data at South Australian teaching hospitals have been used to monitor survivals and treatment in relation to these guidelines. The aim was to use registry data to: (1) investigate trends in survival and treatment; and (2) compare treatment guidelines. Colin G. Luke http://works.bepress.com/colin_luke/4 http://works.bepress.com/colin_luke/4 Mon, 14 Sep 2009 22:17:58 PDT To investigate trends in cervical cancer incidence, mortality and survival by histology for benchmarking purposes ahead of practice change and the introduction of Human Papilloma Virus (HPV) vaccine. Data was used from the South Australian Cancer Registry. Colin G. Luke http://works.bepress.com/colin_luke/3 http://works.bepress.com/colin_luke/3 Mon, 14 Sep 2009 22:00:21 PDT South Australian registry data were used to investigate trends in laryngeal cancer age-standardised incidence, mortality and disease-specific survival from 1977 to 2005. Colin G. Luke http://works.bepress.com/colin_luke/2 http://works.bepress.com/colin_luke/2 Tue, 21 Jul 2009 18:38:51 PDT Objectives: To investigate incidence, mortality and case survival trends for cancer of unknown primary site (CUP) and consider clinical implications. Method: South Australian Cancer Registry data were used to calculate age-standardised incidence and mortality rates from 1977 to 2004. Disease-specific survivals, socio-demographic, histological and secular predictors of CUP, compared with cancers of known primary site, and of CUP histological types, using multivariable logistic regression were investigated. Results: Incidence and mortality rates increased approximately 60% between 1977-80 and 1981-84. Rates peaked in 1993-96. Male to female incidence and mortality rate ratios approximated 1.3:1. Incidence and mortality rates increased with age. The odds of unspecified histological type, compared with the more common adenocarcinomas, were higher for males than females, non-metropolitan residents, low socio-economic areas, and for 1977-88 than subsequent diagnostic periods. CUP represented a higher proportion of cancers in Indigenous patients. Case survival was 7% at 10 years from diagnosis. Factors predictive of lower case survival included older age, male sex, Indigenous status, lower socio-economic status, and unspecified histology type. Conclusion: Results point to poor CUP outcomes, but with a modest improvement in survival. The study identifies socio-demographic groups at elevated risk of CUP and of worse treatment outcomes where increased research and clinical attention are required. Colin Luke