Calderone’s research focuses on the enzymology of natural product biosynthesis. Natural products are a rich source of valuable compounds that include antibiotics, anticancer agents, and other therapeutics. However, it is often difficult or impossible to modify the structures of natural products to increase their effectiveness or lower their toxicity. By increasing our understanding of the pathways by which natural products are generated, the ultimate goal of Calderone’s research is to allow the engineering of modified products with desired properties. Calderone was recently awarded a Dreyfus Foundation Faculty Start-Up Award in support of these efforts. BS, University of Chicago; MPhil, Cambridge University; PhD, Harvard University; Postdoc at Harvard Medical School Calderone has been teaching at Macalester since 2008.
Selected Recent Publications
A ketoreductase domain in the PksJ protein of the bacillaene assembly line carries out both α- and β-ketone reduction during chain growth (with Stephanie B. Bumpus, Neil L. Kelleher, Christopher T. Walsh, and Nathan A. Magarvey), PNAS (2008)
Polyunsaturated fatty-acid-like trans-enoyl reductases utilized in polyketide biosynthesis (with Stephanie B. Bumpus, Nathan A. Magarvey, Neil L. Kelleher, and Cristopher T. Walsh), Journal of the American Chemical Society (2008)
Polyketide biosynthesis is typically directed by cis-acting catalytic domains. In the case of the Bacillus...
Isoprenoid-like alkylations in polyketide biosynthesis, Natural Product Reports (2008)
Poster: Characterization of Enzymes Involved in Biosynthesis of the Hydroxamate-Containing Siderophore Triacetylfusarinine C in Aspergillus nidulans (with Emil Mellgren), Student Research Poster Session (2009)
Poster: Towards the Characterization of Prenylation of the Sirodesmin Precursor Phomamide in Leptosphaeria maculans. (with Christina Fitzsimmons), Student Research Poster Session (2009)
Cloning and Expression of Truncated Polyketide Synthase Enzymes for Structural Analysis. (with Emil Mellgren), Winchell Undergraduate Symposium (2009)