BACKGROUND •Drug treatment populations are disproportionately affected by morbidity and mortality due to tobacco use. However, with appropriately intensive intervention, individuals in drug treatment settings can succeed in their efforts towards smoking cessation. •The Tobacco Dependence Clinic (TDC) is a program that provides smoking cessation counseling and up to 26 weeks of free pharmacotherapy for clients through Vancouver Coastal Health Addiction Services , British Columbia, Canada. There are currently three clinic sites: Pacific Spirit, Three Bridges, and Downtown Community Health Centre (DCHC). •The purpose of this study is to provide 2-year pilot evaluation data (in terms of program completion and smoking cessation outcomes) from the TDC.