The present study used the Minnesota Multiphasic Personality Inventory (MMPI) to select, based on multidimensional criteria, 51 college students who displayed depression alone, depression in conjunction with other psychological disturbance (PD), nondepressive PD, or no PD. All students had been living with randomly assigned roommates (RMs) for at least 10 wks. RMs of these students completed the Multiple Affect Adjective Check List, the Profile of Mood States, MMPI-168 Depression scale items, and items concerning roommate behavior. RMs of students depressed in conjunction with other PD were significantly more depressed themselves on 2 measures than were RMs of students in the other 3 groups. Rejection was suggested by a disproportionately high incidence of RM breakups involving students with this profile type. The severity and/or nature of overall psychological dysfunction, rather than depression per se, may be central to the experiences of significant others.