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Article
Descriptive and longitudinal observations on the relationship of borderline personality disorder and bipolar disorder
American Journal of Psychiatry (2006)
  • John G. Gunderson
  • Igor Weinberg
  • Maria T. Daversa
  • Karsten D. Kueppenbender
  • Mary C. Zanarini
  • M. Tracie Shea
  • Andrew E. Skodol
  • Charles A. Sanislow
  • Shirley Yen
  • Leslie C. Morey
  • Carlos M. Grilo
  • Thomas H. McGlashan
  • Robert L. Stout
  • Ingrid R. Dyck
Abstract

OBJECTIVE: The purpose of this study was to test whether borderline personality disorder is a variant of bipolar disorder by examining the rates of co-occurrence in both disorders, the effects of co-occurrence on a longitudinal course, and whether the presence of either disorder confers the risk for new onsets of the other.

METHOD: A prospective repeated-measures design with reliable independent diagnostic measures and 4 years of follow-up was used to assess 196 patients with borderline personality disorder and 433 patients with other personality disorders.

RESULTS: Patients with borderline personality disorder had a significantly higher co-occurrence of bipolar disorder (19.4%) than did patients with other personality disorders. However, this co-occurrence did not appear to affect the subsequent course of borderline personality disorder. Although only 8.2% of the borderline personality disorder patients developed new onsets of bipolar disorder, this rate was higher than in patients with other personality disorders. Patients with other personality disorders with co-occurring bipolar disorder generally had more new onsets of borderline personality disorder (25%) than did patients with other personality disorders without co-occurring bipolar disorder (10%).

CONCLUSIONS: A modest association between borderline personality disorder and bipolar disorder is reported.

Keywords
  • CLPS,
  • Collaborative Longitudinal Personality Study,
  • Bipolar Disorder,
  • BPD,
  • Borderline Personality Disorder,
  • DSM,
  • DSM-IV,
  • Axis I,
  • Axis II,
  • Personality Disorders
Publication Date
July, 2006
Citation Information
Gunderson, J. G., Weinberg, I., Daversa, M., Kueppenbender, K. D., Zanarini M .C., Shea, M. T., Skodol, A. E., Sanislow, C. A., Yen, S., Morey, L. C., Grilo C. M., McGlashan,T. H., Stout, R. L., & Dyck, I. (2006). Descriptive and longitudinal observations on the relationship of borderline personality disorder and bipolar disorder. American Journal of Psychiatry, 163(7), 1173-1178.