The Duke-NUS Graduate Medical School Singapore (Duke-NUS) Body and Disease course is a 20-week, integrated course occurring at the end of the first year. The course covers four basic science topics: Pathology, Pharmacology, Immunology, and Microbiology and is modelled after the same course from the Duke University School of Medicine (DSOM) in Durham, North Carolina, USA. The structure of the course, as delivered by DSOM, was adapted to meet the needs and structure of the Duke-NUS programme. In addition, the course was adapted significantly to incorporate the Team-Based Learning methodology. In this paper, we detail how we approached these unique challenges. This paper presents an overview of the course structure, preliminary evaluation, and implications for future implementation.