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Selected Works of C. Michele Davis McGibony
Article
A Novel Synthesis of p-Nitrobenzylphosphonic Acid and Its Action on Alkaline Phosphatase
Letters in Organic Chemistry
  • C. Michele Davis McGibony, Georgia Southern University
  • Kevin J. Hand, Georgia Southern University
  • R. Bryan Sears, Georgia Southern University
  • Trianna R. McCall, Georgia Southern University
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Document Type
Article
Publication Date
1-1-2008
DOI
10.2174/157017808785982167
Disciplines
Abstract

p-Nitrobenzylphosphonic acid was obtained via a nucleophilic substitution of nitrobenzyl bromide with trimethyl phosphite as opposed to nitration of benzylphosphonic acid. This compound is a competitive inhibitor of alkaline phosphatase (KI ∼ 125 μM) and has potential to inhibit a wide range of other phosphatases including serine/threonine phosphatases and tyrosine phosphatases.

Citation Information
C. Michele Davis McGibony, Kevin J. Hand, R. Bryan Sears and Trianna R. McCall. "A Novel Synthesis of p-Nitrobenzylphosphonic Acid and Its Action on Alkaline Phosphatase" Letters in Organic Chemistry Vol. 5 Iss. 7 (2008) p. 563 - 565 ISSN: 1875-6255
Available at: http://works.bepress.com/c_davismcgibony/87/