Dr. Brian K. Whitlock was raised in Gravel Switch, Kentucky on a small tobacco and
dairy farm. He attended Campbellsville University where he received his B.S. in Chemistry
in 1997 and Michigan State University for his M.S. in Animal Science in 1999. After
earning his D.V.M. from Auburn University in 2003, Brian worked at Sterner Veterinary
Clinic in Ionia, Michigan almost exclusively on dairy and beef cattle. In 2007 he
completed a residency at Auburn and became a Diplomate of the American College of
Theriogenologists (veterinary reproduction specialists). Dr. Whitlock recently earned his
Ph.D. from Auburn (working with Dr. James L. Sartin) with an emphasis in reproductive
neuroendocrinology and is now an assistant professor at The University of Tennessee
College of Veterinary Medicine. Currently, most of his time is spent with Field Services
teaching and mentoring students in the areas of theriogenology, large animal medicine,
surgery, and production medicine. His current research interests include reproductive
neuroendocrinology and physiology with special emphasis on the use of kisspeptin and
gonadotropin inhibiting hormone in large domestic animals. Dr. Whitlock has two PhD
students, Mrs. Lisa Amelse and Dr. Val Tanco, DVM. Lisa is conducting in vitro studies
with GT1-7 cells and kisspeptin and Dr. Tanco is studying kisspeptin and gonadotropin
inhibiting hormone in cattle. Dr. Whitlock and his wife Lynette, have three children,
Grayson, Lydia, and Truett. 

KISSPEPTIN

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Kisspeptin receptor agonist (FTM080) increased plasma concentrations of luteinizing hormone in anestrous ewes (with Kelly A. Chameroy, Rebecca R. Payton, Shinya Oishi, Nobutaka Fujii, and Joseph A. Daniel), Society for Theriogenology / American College of Theriogenologists Annual Symposia (2013)

Kisspeptin (KP) and the KP receptor (Kiss1r) are integral to central regulation of the gonadotropic-axis....

 

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Hypothalamic Integration of Nutrient Status and Reproduction in the Sheep (with Joseph A. Daniel, Chad D. Foradori, and James L. Sartin), Reproduction in Domestic Animals (2013)

Nutrient availability is a determinant of reproductive success. It is well known that inadequate nutrition...

 

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Effect of Kisspeptin on Regulation of Growth Hormone (with Joseph A. Daniel, Robyn R. Wilborn, Herris S. Maxwell, Barbara P. Steele, and James L. Sartin), Journal of Animal Science and Biotechnology (2011)

Kisspeptin ( KP ), a neuroendocrine regulator of reproduction, is hypothesized to be an integrator...

 

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Interaction of Kisspeptin and the somatotropic axis, NeuroEndoNow (2010)

In addition to activating the gonadotropic axis, kisspeptin can activate the somatotropic axis in ruminants....

 

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Interaction of Kisspeptin and the somatotropic axis (with Joseph A. Daniel, Robyn R. Wilborn, Herris S. Maxwell, Barbara P. Steele, and James L. Sartin), Neuroendocrinology (2010)

Kisspeptin, a regulator of gonadotropin-releasing hormone, has been hypothesized as an integrator of nutrition and...

 

HERITABLE CONGENITAL DEFECTS

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Diploid-Triploid Mixoploidy in an Intersex Goat - Theriogenology Question of the Month (with Elizabeth A. Coffman, Kathryn Y. Bray, Erica L. Himmelreich, and Herris S. Maxwell), Journal of the American Veterinary Medical Association (2013)
 

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Heritable Birth Defects in Cattle, Applied Reproductive Strategies Proceedings (2010)

Inherited congenital anomalies are probably present in all breeds of cattle and propagated as a...

 

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Update on heritable congenital defects in cattle, Clinical Theriogenology (2010)

Inherited congenital anomalies are probably present in all breeds of cattle and propagated as a...

 

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Heritable bovine fetal abnormalities (with Lana Kaiser and Herris S. Maxwell), Theriogenology (2008)

The etiologies for congenital bovine fetal anomalies can be divided into heritable, toxic, nutritional, and...

 

INFECTIOUS DISEASES AND ENDOCRINOLOGY

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Modeling for cost analysis of Johne's Disease control based on evelisa testing (with Tyler Massaro, Suzanne Lenhart, Meredith Spence, Crystal Drakes, Guang Yang, Folashade Augusto, Rachel Johnson, Ashutosh Wadhwa, and Eda Shigetoshi), Journal of Biological Systems (2013)

Use of enzyme-linked immunosorbent assay (ELISA) is recommended for control of Johne's disease (JD) in...

 

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Comparative aspects of the endotoxin- and cytokine-induced endocrine cascade influencing neuroendocrine control of growth and reproduction in farm animals (with Joseph A. Daniel, Robyn R. Wilborn, Ted H. Elsasser, Jeff A. Carroll, and James L. Sartin), REPRODUCTION IN DOMESTIC ANIMALS (2008)

Disease in animals is a well-known inhibitor of growth and reproduction. Earlier studies were initiated...

 

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Interleukin-1beta and tumor necrosis factor-alpha mediation of endotoxin action on growth hormone. (with J A. Daniel, T H. Elsasser, A Martinez, B P. Steele, and J L. Sartin), American Journal of Physiology. Endocrinology and Metabolism (2005)

In humans and sheep, endotoxin (LPS) administration results in increased growth hormone (GH) concentrations. To...

 

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Endotoxin inhibition of luteinizing hormone in sheep, Domestic Animal Endocrinology (2003)

Administration of endotoxin suppresses circulating concentration of luteinizing hormone (LH) in a number of species,...

 

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Estradiol plus progesterone treatment modulates select elements of the proinflammatory cytokine cascade in steers: attenuated nitric oxide and thromboxane B2 production in endotoxemia (with J L. Sartin, T H. Elsasser, S Kahl, J Baker, J A. Daniel, D D. Schwartz, and B Steele), Journal of Animal Science (2003)

Estradiol plus progesterone (EP) implants have been shown to favorably alter the time course or...

 

APPETITE

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Hypothalamic Integration of Nutrient Status and Reproduction in the Sheep (with Joseph A. Daniel, Chad D. Foradori, and James L. Sartin), Reproduction in Domestic Animals (2013)

Nutrient availability is a determinant of reproductive success. It is well known that inadequate nutrition...

 

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Neural regulation of feed intake: Modification by hormones, fasting, and disease (with James L. Sartin and Joseph A. Daniel), Journal of Animal Science (2011)

Appetite is a complex process that results from the integration of multiple signals at the...

 

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Selected hormonal and neurotransmitter mechanisms regulating (with James L. Sartin, Joseph A. Daniel, and Robyn R. Wilborn), Animal (2010)

Appetite control is a major issue in normal growth and in suboptimal growth performance settings....

 

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Central role of the melanocortin-4 receptors in appetite regulation after endotoxin (with James L. Sartin, D L. Marks, Chris D. McMahon, Joseph A. Daniel, P Levasseur, C G. Wagner, and Barbara P. Steele), JOURNAL OF ANIMAL SCIENCE (2008)

Melanocortin-4 receptors (MC4R) are key factors in the depression of appetite during disease. This study...

 

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Long-term feed intake regulation in sheep is mediated by opioid receptors (with F Y. Obese, Barbara P. Steele, Fran C. Buonomo, and James L. Sartin), Journal of Animal Science (2007)

These experiments were conducted to determine if 1) syndyphalin-33 (SD33), a mu-opioid receptor ligand, affects...

 

BOVINE MAMMARY DEVELOPMENT

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Short communication: relationship between body growth and mammary development in dairy heifers (with L F. Silva, M J. VandeHaar, R P. Radcliff, and H A. Tucker), Journal of Dairy Science (2002)

Our objective was to determine if prepubertal rate of body weight (BW) gain, independent of...

 

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Effect of dietary protein on prepubertal mammary development in rapidly growing dairy heifers (with M J. VandeHaar, L F. Silva, and H A. Tucker), Journal of Dairy Science (2002)

The objective was to determine whether increased dietary protein would enhance mammary development in prepubertal...

 

PREGNANCY DIAGNOSIS IN RUMINANTS

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Review of pregnancy diagnosis techniques in cattle and small ruminants (with Elizabeth A. Coffman), Clinical Theriogenology (2010)

Pregnancy diagnosis is a common management practice for ruminants and there are a number of...

 

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Pregnancy-associated glycoproteins and pregnancy wastage in cattle (with Herris S. Maxwell), Theriogenology (2008)

Accurate diagnosis of non-pregnancy and prompt re-enlistment of ‘‘non-pregnant’’ cattle into an appropriate breeding protocol...

 

ANIMAL STRESS AND WELL-BEING

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Effect of meloxicam on gain and behavior of calves castrated by banding pre-weaning (with Joseph A. Daniel and Peter D. Krawczel), ADSA-ASAS Joint Annual Meeting (2013)

The objective was to determine if oral meloxicam (M; a non-steroid anti-inflammatory) administered at castration...

 

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Effect of meloxicam on gain and inflammatory response of calves castrated by banding post-weaning (with Peter D. Krawczel, Jeff A. Carroll, Nicole C. Burdick Sanchez, Jeff W. Dailey, Joseph A. Daniel, and Johann F. Coetzee), ADSA-ASAS Joint Annual Meeting (2013)

Castration may detrimentally affect the health and performance of weaned calves, and painful procedures are...

 

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Meloxicam mediates short-term behavioral changes of castrated calves (with Peter D. Krawczel, Jeff A. Carroll, Nicole C. Burdick Sanchez, Jeff W. Dailey, Joseph A. Daniel, and Johann F. Coetzee), ADSA-ASAS Joint Annual Meeting (2013)

Castration may detrimentally affect the health and performance of weaned calves and painful procedures are...

 

Impact of water and feed deprivation on physiological parameters in steers (with Joseph A. Daniel, Paul H. Walz, Jeff A. Carroll, and Ted H. Elsasser) (2012)

A report in rats demonstrated that dehydration as the result of 8 d of water...

 

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Electroejaculation increased vocalization and plasma concentrations of cortisol and progesterone, but not substance P, in beef bulls (with Elizabeth A. Coffman, Johann F. Coetzee, and Joseph A. Daniel), Theriogenology (2012)

Electroejaculation is a reliable method of obtaining a semen sample for a bull breeding soundness...

 

POSTERS

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Kisspeptin receptor agonist (FTM080) increased plasma concentrations of luteinizing hormone in anestrous ewes (with Kelly A. Chameroy, Rebecca R. Payton, Shinya Oishi, Nobutaka Fujii, and Joseph A. Daniel), Society for Theriogenology / American College of Theriogenologists Annual Symposia (2013)

Kisspeptin (KP) and the KP receptor (Kiss1r) are integral to central regulation of the gonadotropic-axis....

 

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Effect of meloxicam on gain and behavior of calves castrated by banding pre-weaning (with Joseph A. Daniel and Peter D. Krawczel), ADSA-ASAS Joint Annual Meeting (2013)

The objective was to determine if oral meloxicam (M; a non-steroid anti-inflammatory) administered at castration...

 

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Effect of meloxicam on gain and inflammatory response of calves castrated by banding post-weaning (with Peter D. Krawczel, Jeff A. Carroll, Nicole C. Burdick Sanchez, Jeff W. Dailey, Joseph A. Daniel, and Johann F. Coetzee), ADSA-ASAS Joint Annual Meeting (2013)

Castration may detrimentally affect the health and performance of weaned calves, and painful procedures are...

 

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Meloxicam mediates short-term behavioral changes of castrated calves (with Peter D. Krawczel, Jeff A. Carroll, Nicole C. Burdick Sanchez, Jeff W. Dailey, Joseph A. Daniel, and Johann F. Coetzee), ADSA-ASAS Joint Annual Meeting (2013)

Castration may detrimentally affect the health and performance of weaned calves and painful procedures are...

 

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Heifer estrous cycle stage impacts luteinizing and growth hormone response to kisspeptin (with Joseph A. Daniel, Robyn R. Wilborn, Barbara P. Steele, and James L. Sartin) (2011)

The reproductive neuropeptide, kisspeptin (KP), may have a role in regulation of growth hormone (GH)...

 

Mobile Teaching and Learning

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Development of a Mobile Teaching and Learning Module for VM893 (Field Services) with (2011)

The goal of this project is to develop a teaching and learning module with interactive...

 

NEWSLETTERS

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Farm Focus - Spring 2010 (with Matt Welborn, Maria Prado, and Amy Plummer) (2010)
 

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Farm Focus - Fall 2009 (with Matt Welborn, Maria Prado, and Amy Plummer) (2009)
 

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Farm Focus - Spring 2009 (with Matt Welborn, Maria Prado, and Amy Plummer) (2009)
 

MISC

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Bovine Trichomoniasis in Tennessee (with Clare Scully), Tennessee Cattle Business (2012)
 

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Faculty Appreciation Week College Kudos: College of Veterinary Medicine (2011)

Brian Whitlock doesn’t remember exactly when he decided to become a veterinarian. It’s just who...

 

BOVINE REPRODUCTION

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Bulls grazing Kentucky 31 tall fescue exhibit impaired growth, semen quality, and decreased semen freezing potential (with S L. Pratt, H M. Stowe, L Strickland, M Miller, S M. Calcatera, M D. Dimmick, G E. Aiken, F N. Schrick, N M. Long, S K. Duckett, and J G. Andrae), Theriogenology (2014)

Serum prolactin (PRL) and testosterone concentrations, body weight, body composition, semen quality, and semen freezing...

 

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Effect of the first GnRH and two doses of PGF2α in a 5-day progesterone-based CO-Synch protocol on heifer pregnancy. (with R K. Kasimanickam, P Firth, G M. Schuenemann, J M. Gay, D A. Moore, J B. Hall, and W D. Whittier), Theriogenology (2014)

The objectives were (1) to determine the effects of gonadorelin hydrochloride (GnRH) injection at controlled...

 

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Bovine Trichomoniasis in Tennessee (with Clare Scully), Tennessee Cattle Business (2012)
 

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Physiologic and antinociceptive effects following intramuscular administration of xylazine hydrochloride in combination with tiletamine-zolazepam in llamas (with R Seddighi, Sarah B. Elliot, Christine Egger, and Thomas J. Doherty), American Journal of Veterinary Research (2013)

Objective-To evaluate antinociceptive and selected effects associated with IM administration of xylazine hydrochloride in combination...