Effective Oral Favipiravir (T-705) Therapy Initiated after the Onset of Clinical
Disease in a Model of Arenavirus Hemorrhagic Fever (with M. Mendenhall, A. Russell, Donald F. Smee, Jeffery O. Hall, Ramona T. Skirpstunas, and Y. Furuta), PLoS Neglected Tropical Diseases (2011)
Maporal virus as a
surrogate for pathogenic New World hantaviruses and its inhibition by favipiravir (with K. K. Buys, K. H. Jung, D. F. Smee, and Y. Furuta), Antiviral Chemistry & Chemotherapy (2011)
Progress in the experimental therapy of severe arenaviral
infections (with M. Bray), Future Microbiology (2011)
(Favipiravir) inhibition of arenavirus replication in cell culture (with M. Mendenhall, A. Russell, T. Juelich, E. L. Messina, D. F. Smee, A. N. Freiberg, M. R. Holbrook, Y. Furuta, J. C. de la Torre, and J. H. Nunberg), Antimicrobial Agents and Chemotherapy (2011)
recombinant adenovirus vectored 1 consensus IFN-α to avert severe arenavirus infection (with J. Ennis, A. Russell, E. J. Sefing, M. H. Wong, and J. Turner), PLoS ONE (2011)
Assessing changes in vascular permeability in a hamster model of
viral hemorrhagic fever (with J. G. Julander, N. R. London, M. H. Wong, D. Larson, J. D. Morrey, D. Y. Li, and M. Bray), Virology Journal (2010)
Development of a new Tacaribe
arenavirus infection model and its use to explore antiviral activity of a novel
aristeromycin analog (with M. H. Wong, D. Larson, W. Ye, K. H. Jung, E. J. Sefing, R. Skirpstunas, D. F. Smee, J. D. Morrey, and S. W. Schneller), PLoS ONE (2010)
Efficacy of favipiravir (T-705) and T-1106 pyrazine derivatives in phlebovirus disease
models (with M. H. Wong, K. H. Jung, D. F. Smee, J. D. Morrey, and Y. Furuta), Antiviral Research (2010)
A biotechnological product and its potential as a new immunomodulator for
treatment of animal phlebovirus infection: Punta Toro virus (with N. Duran, F. T. Costa, G. Z. Justo, M. Brocchi, O. S. Nunes, and I. S. Nunes), Antiviral Research (2009)
Prophylaxis with cationic liposome-DNA complexes protects hamsters
from phleboviral disease: importance of liposomal delivery and CpG motifs (with J. Fairman, S. W. Dow, R. Troyer, M. H. Wong, K. H. Jung, P. C. Melby, and J. D. Morrey), Antiviral Research (2009)
Toro virus (Bunyaviridae, Phlebovirus) infection in mice: strain differences in
pathogenesis and host interferon response (with M. Mendenhall, M. H. Wong, R. Skirpstunas, and J. D. Morrey), Virology (2009)
T-705 (favipiravir) and related compounds: Novel
broad-spectrum inhibitors of RNA viral infections (with Y. Furuta, K. Takahashi, K. Shiraki, K. Sakamoto, Donald F. Smee, Dale L. Barnard, Justin G. Julander, and John D. Morrey), T-705 (favipiravir) and related compounds: Novel
broad-spectrum inhibitors of RNA viral infections (2009)
Animal models of highly pathogenic RNA viral
infections: Encephalitis viruses (with M. R. Holbrook), Antiviral Research (2008)
Animal models of highly pathogenic RNA viral
infections: Hemorrhagic fever viruses (with M. R. Holbrook), Antiviral Research (2008)
Immunoprophylaxis of Punta Toro virus (Phlebovirus,
Bunyaviridae) infection in hamsters with recombinant Eimeria profilin-like antigen. (with J. W. Judge, M. H. Wong, K. H. Jung, C. F. Aylsworth, P. C. Melby, B. Rosenberg, and J. D. Morrey), International Immunopharmacology (2008)
Potent in vitro activity of the albumin fusion type 1interferons (albumin-interferon-alpha and albumin-interferon-beta) against RNA viral agentsof bioterrorism and the severe acute respiratory syndrome (SARS) virus (with G. M. Subramanian, P. A. Moore, Aaron L. Olsen, Dale L. Barnard, J. Paragas, R. J. Hogan, and R. W. Sidwell), Chemotherapy (2008)
Background: The type 1 interferons (INF-α and INF-β) are potent antiviral agents. Albumin-INF-α and albumin-INF-β...
therapeutic intervention of Punta Toro virus (Phlebovirus, Bunyaviridae) infection in
hamsters with Interferon Alfacon-1 (with M. H. Wong, K. H. Jung, L. M. Blatt, and R. W. Sidwell), Antiviral Research (2008)
T-705 Treatment of Late Stage Disease in an Arenaviral Hemorrhagic Fever Model:
T-705 Efficacy and Reduced Toxicity Suggests a Viable Alternative to Ribavirin
Therapy (with Donald F. Smee, Jeffery O. Hall, M. Wong, K. Jung, K. W. Bailey, J. R. Stevens, Y. Furuta, and John D. Morrey), PLoS ONE (2008)
Treatment of late stage disease in a model of arenaviral
hemorrhagic fever: T-705 efficacy and reduced toxicity suggests a viable alternative to
ribavirin therapy (with D. F. Smee, M. H. Wong, J. O. Hall, K. H. Jung, K. W. Bailey, J. R. Stevens, Y. Furuta, and J. D. Morrey), PLoS ONE (2008)
Differential Pathogenesis of Cowpox Virus Intranasal Infections in Mice Induced by Low and High Inoculum Volumes and Effects of Cidofovir Treatment (with Donald F. Smee, M. K. Wandersee, M-H. Wong, Ramona T. Skirpstunas, Thomas J. Baldwin, J. D. Hoopes, and R. W. Sidwell), International Journal of Antimicrobial Agents (2007)
The causes of death from intranasal cowpox virus infections in mice remain unclear. Hypotheses include...
sequencing reveals toll-like receptor variants contribute to human susceptibility to
tuberculosis disease (with X. Ma, Y. Liu, E. A. Graviss, A. G. Clark, and J. M. Musser), PLoS ONE (2007)
In Vitro and In Vivo Activities of T-705 against Arenavirus and Bunyavirus Infections (with M. Wong, K. Jung, A. B. Sanders, M. Mendenhall, K. W. Bailey, Y. Furuta, and R. W. Sidwell), Antimicrobial Agents and Chemotherotherapy (2007)
There is a need for the development of effective antivirals for the treatment of severe...
Novel 3-Sulphonamido-Quinazolin-4(3H)-One Derivatives: Microwave-Assisted Synthesis and Evaluation of Antiviral Activities against Respiratory and Biodefense Viruses (with P. Selvam, P. Vijayalakshimi, Donald F. Smee, Justin G. Julander, C. W. Day, and Dale L. Barnard), Antiviral Chemistry and Chemotherapy (2007)
We designed and synthesized novel 2,3-disubstituted quinazolin-4(3H)-ones by microwave technique and characterized them by spectral...
TLR3 Is Essential for the Induction of Protective Immunity against Punta Toro Virus Infection by the Double-Stranded RNA (dsRNA), Poly(I:C12U), but not Poly(I:C): Differential Recognition of Synthetic dsRNA Molecules (with M. Wong, K. Jung, W. M. Mitchell, A. B. Sanders, L. Alexopoulou, R. A. Flavell, and R. W. Sidwell), Journal of Immunology (2007)
In the wake of RNA virus infections, dsRNA intermediates are often generated. These viral pathogen-associated...
Combinatorial Ribavirin and Interferon Alfacon-1 Therapy of Acute Arenaviral Disease in Hamsters (with Donald F. Smee, M. Wong, A. M. Pace, K. Jung, K. W. Bailey, L. M. Blatt, and R. W. Sidwell), Antiviral Chemistry and Chemotherapy (2006)
Several arenaviruses endemic to South America (Junin, Machupo, and Guanarito) and Africa (Lassa) are known...
Protective Immunity against Acute Phleboviral Infection Elicited through Immunostimulatory Cationic Liposome-DNA Complexes (with J. Fairman and Donald F. Smee), Antiviral Research (2006)
Cationic liposome-DNA complexes (CLDC) have been demonstrated to induce potent antitumor activities. The ability of...
Recombinant Eimeria Protozoan Protein Elicits Resistance to Acute Phlebovirus Infection in Mice but Not Hamsters (with Donald F. Smee, M. Wong, J. W. Judge, K. Jung, K. W. Bailey, A. M. Pace, B. Rosenberg, and R. W. Sidwell), Antimicrobial Agents and Chemotherotherapy (2006)
A protein antigen from an Eimeria protozoan has recently been reported to induce antitumor activity...
TLR3 Deletion Limits Mortality and Disease Severity due to Phlebovirus Infection (with J. D. Hoopes, M. Wong, K. Jung, K. C. Isakson, L. Alexpoulou, R. A. Flavell, and R. W. Sidwell), Journal of Immunology (2006)
TLR3 was the first member of the TLR family of pattern recognition receptors found to...
Group A Streptococcus Transcriptome Dynamics during Growth in Human Blood Reveals Bacterial Adaptive and Survival Strategies (with M. R. Graham, K. Virtaneva, S. F. Porcella, W. T. Barry, C. A. Johnson, F. A. Wright, and J. M. Musser), American Journal of Pathology (2005)
The molecular basis for bacterial responses to host signals during natural infections is poorly understood....
Interferon Alfacon-1 Protects Hamsters from Lethal Pichinde Virus Infection (with Dale L. Barnard, Donald F. Smee, M. H. Wong, A. M. Pace, K. H. Jung, S. G. Winslow, K. W. Bailey, L. M. Blatt, and R. W. Sidwell), Antimicrobial Agents and Chemotherotherapy (2005)
Hemorrhagic fever of arenaviral origin is a frequently fatal infectious disease of considerable priority to...
Kinetics of Disease Progression and Host Response in a Rat Model of Bubonic Plague (with F. Sebbane, D. Gardner, D. Long, and B. J. Hinnebusch), American Journal of Pathology (2005)
Plague, caused by the gram-negative bacterium Yersinia pestis, primarily affects rodents but is also an...
Variation in Lipid A Structure in the Pathogenic Yersiniae (with R. Rebeil, R. K. Ernst, S. I. Miller, and B. J. Hinnebusch), Molecular Microbiology (2004)
Important pathogens in the genus Yersinia include the plague bacillus Yersinia pestis and two enteropathogenic...
Insight into the
molecular basis of pathogen abundance: group A Streptococcus inhibitor of complement
inhibits bacterial adherence and internalization into human cells (with N. P. Hoe, R. M. Ireland, F. R. Deleo, D. W. Dorward, J. M. Voyich, M. Liu, E. H. Burns Jr., D. M. Culnan, A. Bretscher, and J. M. Musser), Proceedings of the National Academy of Sciences of the United States of America (2002)
The collagenous domain of class
A scavenger receptors is involved in macrophage adhesion to collagens (with T. K. Borg, A. Ghaffar, and E. P. Mayer), Journal of Leukocyte Biology (2001)