Recent investigations have shown excess post-exercise oxygen consumption (EPOC) to be elevated for up to 48 hrs in both untrained and trained subjects following resistance training (RT). The purpose of the present study was to investigate the effect of load-volume on EPOC. Eight (n = 8) trained males (22 ± 3 yrs.) participated in two randomized RT bouts separated by at least one wk with total load-volumes of 10,000 kg and 20,000 kg. Intensity of RT (85% 1RM) did not differ between trials. Exercise energy expenditure and resting metabolic rate (RMR) were measured by indirect calorimetry at 8.5 hr prior, 1.5 hr prior, and during RT bouts as well as 12, 24, 36, and 48 hr following exercise. Creatine kinase (CK) was measured before and after RT, as well as 12, 24, 36, and 48 hr post-exercise; ratings of perceived muscle soreness (RPMS) were measured on a similar time course save the immediate post-exercise time point. ANOVA with repeated measures was used to analyze dependent variables. During the 20,000 kg trial subjects expended significantly (p < 0.01) more energy (484 ± 29 kcal) than the 10,000 kg lift (247 ± 18 kcal). Following the 20,000 kg lift, 12 hr post-exercise CK (1159 ± 729 U/L) was significantly elevated (p < 0.05) as compared to baseline (272 ± 280 U/L) and immediately post-exercise (490 ± 402 U/L). No significant time or trial differences were found in RMR between the 10,000 kg and 20,000 kg trials. In conclusion, high intensity RT with load-volumes of up to 20,000 kg using resistance trained males does not significantly increase EPOC above baseline RMR.