Experimental Versus Numerical Data for Breast Cancer Progression

Cheryl L. Jorcyk, Boise State University
M. Kolev, University of Warmia and Mazury
Ken Tawara, Boise State University
Barbara Zubik-Kowal, Boise State University

Abstract

This paper deals with a mouse model of breast cancer based on two mammary adenocarcinoma cell lines derived from a spontaneous tumor of the mammary gland in a female BALB/c mouse. We investigate both animal and mathematical models of tumor progression, and demonstrate a correspondence between the experimental and predicted data. The mathematical model is solved numerically and the laboratory data are utilized in order to find unknown parameters for the model equations. The results of the numerical experiments illustrate that the mathematical model has a potential to describe the growth of cancer cells in vivo.