Association between dietary glycemic index, glycemic load, and high-sensitivity C-reactive protein
OBJECTIVE: This study examined the relation between quality of dietary carbohydrate intake, as measured by glycemic index (GI) and glycemic load (GL), and serum high-sensitivity C-reactive protein (hs-CRP) levels.
METHODS: During a 1-y observational study, data were collected at baseline and at each quarter thereafter. GI and GL were calculated from multiple 24-h dietary recalls (24HRs), 3 randomly selected 24HRs at every quarter, with up to 15 24HRs per participant. The hs-CRP was measured in blood samples collected at baseline and each of the four quarterly measurement points. Multivariable linear mixed models were used to examine the cross-sectional and longitudinal associations of GI, GL, and hs-CRP.
RESULTS: Among 582 adult men and women with at least two measurements of diet and hs-CRP, average daily GI score (white bread = 100) was 85 and average GL was 198, and average hs-CRP was 1.84 mg/L. Overall, there was no association between GI or GL and hs-CRP. Subgroup analyses revealed an inverse association between GL and hs-CRP among obese individuals (body mass index > or =30 kg/m(2)).
CONCLUSION: Quality of dietary carbohydrates does not appear to be associated with serum hs-CRP levels. Among obese individuals, higher dietary GL appears to be related to lower hs-CRP levels. Due to the limited number of studies on this topic and their conflicting results, further investigation is warranted.
Jennifer A. Griffith, Yunsheng Ma, Lisa Chasan-Taber, Barbara C. Olendzki, David E. Chiriboga, Edward J. Stanek, Philip A. Merriam, and Ira S. Ockene. "Association between dietary glycemic index, glycemic load, and high-sensitivity C-reactive protein" Nutrition (Burbank, Los Angeles County, Calif.) 24.5 (2008).
Available at: http://works.bepress.com/barbara_olendzki/17