The concept of Greenway has been gaining strength in its role as an organizational strategy for the matrix of open, naturalistic, urban spaces. Multi-disciplinary approaches and methods have increasingly making their way into the Greenway design and planning. Multidisciplinary infusions and ongoing evolution of Greenway thinking, places a demand for a frame that facilitates a systematic understanding, synthesis and tracking of the changes in thinking and Practice since a clear understanding of the current is fundamental to craft the future. As a response to this need of a universal frame, the paper explores and advocates for a Steadmanian frame of Genotype and Phenotype. A targeted review of ecology-oriented Greenways is undertaken for synthesis of emergent theories, design approaches and Practice over the past decade. In conclusion, the article provides clarity to the emergent multi-disciplinary knowledge base, elucidates the genotype, or core principles, of Greenway design thinking and Practice and presents an interdisciplinary universal frame for systematic articulation, presentation and tracking of multidisciplinary Greenway approaches. The article is one in the series on experiments in integration of other, scientific frames in design thinking.