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Article
Muscle Contraction Duration and Fibre Recruitment Influence Blood Flow and VO2 Independent of Contractile Work during Steady-State Exercise in Humans
Experimental Physiology
  • Jennifer C. Richards, Colorado State University - Fort Collins
  • Anne R. Crecelius, University of Dayton
  • Brett S. Kirby, Duke University Medical Center
  • Dennis G. Larson, Medical Center of the Rockies Foundation
  • Frank A. Dinenno, Colorado State University - Fort Collins
Document Type
Article
Publication Date
6-1-2012
Abstract

We tested the hypothesis that, among conditions of matched contractile work, shorter contraction durations and greater muscle fibre recruitment result in augmented skeletal muscle blood flow and oxygen consumption (O2) during steady-state exercise in humans. To do so, we measured forearm blood flow (FBF; Doppler ultrasound) during 4 minutes of rhythmic handgrip exercise in 24 healthy young adults and calculated forearm O2 via blood samples obtained from a catheter placed in retrograde fashion into a deep vein draining the forearm muscle. In Protocol 1 (n = 11), subjects performed rhythmic isometric handgrip exercise at mild and moderate intensities under conditions in which tension time index (TTI; isometric analog of work) was held constant but contraction duration was manipulated. In this protocol, shorter contraction durations led to greater FBF (184 ± 25 vs. 164 ± 25 ml·min-1) and O2 (23 ± 3 vs. 17 ± 2 ml·min-1; both PPper se during steady-state exercise in humans.

Inclusive pages
750-761
ISBN/ISSN
0958-0670
Document Version
Postprint
Comments

This is the peer-reviewed version of the following article:

Richards, J.C., A.R. Crecelius, B.S. Kirby, D.G. Larson and F.A. Dinenno. “Muscle contraction duration and fibre recruitment influence blood flow and VO2 independent of contractile work during steady-state exercise in humans.” Exp Physiol. 97:750-761. 2012.

This article may be used for non-commercial purposes in accordance with Wiley terms and conditions for self-archiving. Article has been published and is available in its final form online.

The article available in the repository is the author's accepted manuscript; the version of record may contain minor differences that have come about in the copy editing and layout processes.

Publisher
Physiological Society
Peer Reviewed
Yes
Keywords
  • vasodilatation,
  • vasodilation,
  • metabolic cost,
  • oxygen delivery
Citation Information
Jennifer C. Richards, Anne R. Crecelius, Brett S. Kirby, Dennis G. Larson, et al.. "Muscle Contraction Duration and Fibre Recruitment Influence Blood Flow and VO2 Independent of Contractile Work during Steady-State Exercise in Humans" Experimental Physiology Vol. 97 (2012)
Available at: http://works.bepress.com/anne_crecelius/6/