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Frequencies of sickle cell trait and glucose-6-phosphate dehydrogenase deficiency differ in highland and nearby lowland malaria-endemic areas of Kenya

Ann M. Moormann, University of Massachusetts Medical School
Paula E. Embury, Case Western Reserve University
J. Opondo, Kenya Medical Research Institute
Peter Odada Sumba, Kenya Medical Research Institute
J. H. Ouma, Kenya Medical Research Institute
James W. Kazura, Case Western Reserve University
Chandy C. John, Case Western Reserve University

Abstract

Sickle cell genotype prevalence was 26% in a malaria-holoendemic lowland area compared with 3% in a highland area of Kenya. The prevalence of glucose-6-phosphate dehydrogenase deficiency was 7% and 1% in holoendemic lowland and highland areas, respectively. Lack of protective polymorphisms may contribute to morbidity and mortality during outbreaks of malaria in the highlands.

Suggested Citation

Ann M. Moormann, Paula E. Embury, J. Opondo, Peter Odada Sumba, J. H. Ouma, James W. Kazura, and Chandy C. John. "Frequencies of sickle cell trait and glucose-6-phosphate dehydrogenase deficiency differ in highland and nearby lowland malaria-endemic areas of Kenya" Transactions of the Royal Society of Tropical Medicine and Hygiene 97.5 (2004).
Available at: http://works.bepress.com/ann_moormann/29