In this paper, the tensile deformation and fracture behavior of commercially pure titanium and the titanium alloy (Ti-6Al-4V) are presented and briefly discussed. Samples of both commercially pure titanium and the Ti-6Al-4V alloy were prepared from the as-provided plate stock along both the longitudinal and transverse orientations. The specimens were then deformed to failure in uniaxial tension. The intrinsic influence of material composition and test specimen orientation on microstructure, tensile properties, and resultant fracture behavior of the two materials is presented. The conjoint influence of intrinsic microstructural features, nature of loading, and specimen orientation on tensile properties of commercially pure titanium and the Ti-6Al-4V alloy is highlighted. The fracture behavior of the two materials is discussed taking into consideration the nature of loading, specimen orientation, and the role and contribution of intrinsic microstructural effects.