Relationships between personality and vocational interest factors were examined at the phenotypic and genetic levels. Twins and siblings (N = 516) completed self-report personality and vocational interest scales. Following factor analyses of each scale, five personality and six vocational interest factors were extracted. At the phenotypic level, correlations between personality and vocational interests ranged from zero to .33. Heritability estimates of the scales showed that genetic components accounted for 0–56% of the variance for the vocational interest factors and 44–65% for the personality factors. Genetic correlations between the two areas ranged from zero to .50. The results suggest that personality is related to some vocational interest dimensions and that some of these observed relationships have a common genetic basis.