Article
Quantifying Effect of Geographic Location on Epidemiology of Plasmodium vivax Malaria
Emerging Infectious Diseases
(2013)
Abstract
Recent autochthonous transmission of Plasmodium vivax malaria in previously malaria-free temperate regions has generated renewed interest in the epidemiology of this disease. Accurate estimates of the incubation period and time to relapse are required for effective malaria surveillance; however, this information is currently lacking. By using historical data from experimental human infections with diverse P. vivax strains, survival analysis models were used to obtain quantitative estimates of the incubation period and time to first relapse for P. vivax malaria in broad geographic regions. Results show that Eurasian strains from temperate regions have longer incubation periods, and Western Hemisphere strains from tropical and temperate regions have longer times to relapse compared with Eastern Hemisphere strains. The diversity in these estimates of key epidemiologic parameters for P. vivax supports the need for elucidating local epidemiology to inform clinical follow-up and to build an evidence base toward global elimination of malaria.
Disciplines
Publication Date
2013
DOI
http://dx.doi.org/10.3201/eid1907.121674
Citation Information
Andrew A. Lover and Richard J. Coker. "Quantifying Effect of Geographic Location on Epidemiology of Plasmodium vivax Malaria" Emerging Infectious Diseases (2013) Available at: http://works.bepress.com/andrew-lover/6/
Creative Commons license
This work is licensed under a Creative Commons CC_BY International License.