AIM: Duration of untreated psychosis (DUP), which has emerged as a reliable predictor of outcome continues to remain under scientific scrutiny . The present study examines effect of differential periods of DUP on long-term outcome of first episode schizophrenia at Mumbai, India. Method: This is a prospective, ten year follow up naturalistic study. Hospitalized patients of first episode schizophrenia were selected and followed up Results: The mean DUP was higher for group, which showed clinical recovery on Clinical Global Impression Scale [14.0 months (SD=8.0) in recovered and 10.8 months (SD=5.7) in non-recovered group (p=0.091)]. DUP was not found to be significantly associated with any of the end point parameters of good clinical or social outcome. Conclusion: This study found that DUP alone does not determine outcome status confirming the role of psychopathological heterogeneity.