Though Psychiatric and neuroscience research has made revolutionary advancements, a number of challenges remain as a barrier in decoding the metrics of psychopathology which intern limits the clinical practice of personalized medicine. In last 20 years a unique direction of research has come to light which provides information about the intricate connections between various findings from the field of neuroimaging, cognition, neurochemistry, molecular biology, immunology and epigenetics. Neurohormores have clearly demonstrated their role in explaining this interrelationship and therefore a possible trajectory for development of mental disorders seem to be visible. Main thrust of investigation which have provided newer insight in psychobiology of mental disorders comes from excellent work providing near unequivocal evidence from research in the field of stress and trauma, childhood adverse events, HPA axis, and HPT axis. There is some indication that early adverse events and abuse can cause later onset illnesses compounded by sustained influence of traumatic event. Neuroencrocrimnal changes modulate not only early brain maturation but also neurocognitive and neuroimaging changes seen in depression and related disorders. Further neuroendocrine are beginning to establish their role in both inflammatory and immunological theories for pathogenesis. This provides a newer hope and excitement for psychoneuroendocrine based treatments. .