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Modifications in Perfringolysin O Domain 4 Alter the Cholesterol Concentration Threshold Required for Binding (with Benjamin B. Johnson, Paul C. Moe, David Wang, Kathleen Rossi, and Bernardo L. Trigatti), Biochemistry (2012)
Changes in the cholesterol content of cell membranes affect many physiological and pathological events, including...
Efficient isolation of Pseudomonas aeruginosa type III secretion translocators and assembly of heteromeric transmembrane pores in model membranes (with Fabian B. Romano, Kyle C. Rossi, Christos G. Sava, Andreas Holzenburg, and Eugenia M. Clerico), Biochemistry (2011)
Translocation of bacterial toxins or effectors into host cells using the type III secretion (T3S)...
The SV40 late protein VP4 is a viroporin that forms pores to disrupt membranes for viral release (with Kristen M. Giorda, F. B. Romano, and Daniel Hebert), PLoS Pathogens (2011)
Nonenveloped viruses are generally released by the timely lysis of the host cell by a...
The Transition from Closed to Open Conformation of Treponema pallidum Outer Membrane-associated Lipoprotein TP0453 Involves Membrane Sensing and Integration by Two Amphipathic Helices (with Amit Luthra, Guangyu Zhu, Daniel C. Desrosiers, Christian H. Eggers, Vishwaroop Mulay, Arvind Anand, Fiona A. McArthur, Fabian B. Romano, Melissa J. Caimano, Michael G. Malkowski, and Justin D. Radolf), Journal of Biological Chemistry (2011)
The molecular architecture and composition of the outer membrane (OM) of Treponema pallidum (Tp), the...
Cholesterol Exposure at the Membrane Surface Is Necessary and Sufficient to Trigger Perfringolysin O Binding (with John J. Flanagan, Rodney K. Tweten, and Arthur E. Johnson), Biochemistry (2009)
Perfringolysin O (PFO) is the prototype for the cholesterol-dependent cytolysins, a family of bacterial pore-forming...