Research and Development (R&D) management in Iran is faced to many barriers and obstacles, in which R&D units are considered as the basic core of the product development and innovation. Due to structural shortcomings, a great number of organizations and industries have not been able to find their actual status. There are about different 1141 R&D units with a dispersion pattern in Iran. This paper considers and analyzes the R&D case study in one of the provinces located in the north part of Iran in order to enhance the potential R&D activities in respect with the industrialized areas and zones. In this province, there are about 2504 industrial units of which there are only 44 R&D units certified by the state government. However, there are limit numbers of these R&D units that are extensively active. This paper also addresses the current status in respect with the R&D activities to find out why there is a lack and depression of these activities in the industrial units. By considering the opportunity and challenges of these R&D units, there is a need to change these units to be active in order to quickly respond the market and demand requirements. Finally, a few alternative solutions and improvement plans are proposed, in which the Iranian R&D Society is responsible for supporting and succeeding these action plans towards the organization goals.