Doxorubicin

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Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma (with Michiro Susa, Keinosuke Ryu, Edwin Choi, Francis John Hornicek, Henry J. Mankin, Lara Milane, Mansoor M. Amiji, and Zhenfeng Duan), Bouvé Faculty Publications (2010)

Background: The use of neo-adjuvant chemotherapy in treating osteosarcoma has improved patients’ average 5 year...

 

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Doxorubicin loaded polymeric nanoparticulate delivery system to overcome drug resistance in osteosarcoma (with Michiro Susa, Keinosuke Ryu, Francis John Hornicek, Henry J. Mankin, Mansoor M. Amiji, and Zhenfeng Duan), Bouvé Faculty Publications (2009)

Background: Drug resistance is a primary hindrance for the efficiency of chemotherapy against osteosarcoma. Although...

 

Osteosarcoma

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Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma (with Michiro Susa, Keinosuke Ryu, Edwin Choi, Francis John Hornicek, Henry J. Mankin, Lara Milane, Mansoor M. Amiji, and Zhenfeng Duan), Bouvé Faculty Publications (2010)

Background: The use of neo-adjuvant chemotherapy in treating osteosarcoma has improved patients’ average 5 year...

 

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Doxorubicin loaded polymeric nanoparticulate delivery system to overcome drug resistance in osteosarcoma (with Michiro Susa, Keinosuke Ryu, Francis John Hornicek, Henry J. Mankin, Mansoor M. Amiji, and Zhenfeng Duan), Bouvé Faculty Publications (2009)

Background: Drug resistance is a primary hindrance for the efficiency of chemotherapy against osteosarcoma. Although...

 

Drug resistance in cancer cells

Hyaluronic acid based self-assembling nanosystems for CD44 target mediated siRNA delivery to solid tumors., Biomaterials (2013)

Anticancer therapeutics employing RNA interference mechanism holds promising potentials for sequence-specific silencing of target genes....

 

PDF

Combinatorial-designed multifunctional polymeric nanosystems for tumor-targeted therapeutic delivery., Accounts of Chemical Research (2011)

By definition, multifunctional nanosystems include several features within a single construct so that these devices...

 

PDF

Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma (with Michiro Susa, Keinosuke Ryu, Edwin Choi, Francis John Hornicek, Henry J. Mankin, Lara Milane, Mansoor M. Amiji, and Zhenfeng Duan), Bouvé Faculty Publications (2010)

Background: The use of neo-adjuvant chemotherapy in treating osteosarcoma has improved patients’ average 5 year...

 

PDF

Doxorubicin loaded polymeric nanoparticulate delivery system to overcome drug resistance in osteosarcoma (with Michiro Susa, Keinosuke Ryu, Francis John Hornicek, Henry J. Mankin, Mansoor M. Amiji, and Zhenfeng Duan), Bouvé Faculty Publications (2009)

Background: Drug resistance is a primary hindrance for the efficiency of chemotherapy against osteosarcoma. Although...

 

Drug delivery systems

Hyaluronic acid based self-assembling nanosystems for CD44 target mediated siRNA delivery to solid tumors., Biomaterials (2013)

Anticancer therapeutics employing RNA interference mechanism holds promising potentials for sequence-specific silencing of target genes....

 

PDF

Fluorescence-guided optical coherence tomography imaging for colon cancer screening: a preliminary mouse study., Biomed Opt Express. (2012)

A new concept for cancer screening has been preliminarily investigated. A cancer targeting agent loaded...

 

PDF

Combinatorial-designed multifunctional polymeric nanosystems for tumor-targeted therapeutic delivery., Accounts of Chemical Research (2011)

By definition, multifunctional nanosystems include several features within a single construct so that these devices...

 

PDF

Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma (with Michiro Susa, Keinosuke Ryu, Edwin Choi, Francis John Hornicek, Henry J. Mankin, Lara Milane, Mansoor M. Amiji, and Zhenfeng Duan), Bouvé Faculty Publications (2010)

Background: The use of neo-adjuvant chemotherapy in treating osteosarcoma has improved patients’ average 5 year...

 

PDF

Doxorubicin loaded polymeric nanoparticulate delivery system to overcome drug resistance in osteosarcoma (with Michiro Susa, Keinosuke Ryu, Francis John Hornicek, Henry J. Mankin, Mansoor M. Amiji, and Zhenfeng Duan), Bouvé Faculty Publications (2009)

Background: Drug resistance is a primary hindrance for the efficiency of chemotherapy against osteosarcoma. Although...

 

PDF

Oxystress inducing antitumor therapeutics via tumor-targeted delivery of PEG-conjugated D-amino acid oxidase., Int J Cancer (2008)

We had developed a H(2)O(2) generating enzyme, polyethylene glycol conjugated D-amino acid oxidase (PEG-DAO), which...

 

PDF

High-loading nanosized micelles of copoly(styrene-maleic acid)-zinc protoporphyrin for targeted delivery of a potent heme oxygenase inhibitor., Biomaterials (2007)

Amphiphilic styrene-maleic acid (SMA) copolymer efficiently formed micelles with a potent heme oxygenase inhibitor-zinc protoporphyrin...

 

PDF

Exploiting the enhanced permeability and retention effect for tumor targeting., Drug Discov Today. (2006)

Of the tumor targeting strategies, the enhanced permeability and retention (EPR) effect of macromolecules is...

 

Tumor Targeting

Hyaluronic acid based self-assembling nanosystems for CD44 target mediated siRNA delivery to solid tumors., Biomaterials (2013)

Anticancer therapeutics employing RNA interference mechanism holds promising potentials for sequence-specific silencing of target genes....

 

PDF

Fluorescence-guided optical coherence tomography imaging for colon cancer screening: a preliminary mouse study., Biomed Opt Express. (2012)

A new concept for cancer screening has been preliminarily investigated. A cancer targeting agent loaded...

 

PDF

Combinatorial-designed multifunctional polymeric nanosystems for tumor-targeted therapeutic delivery., Accounts of Chemical Research (2011)

By definition, multifunctional nanosystems include several features within a single construct so that these devices...

 

PDF

Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma (with Michiro Susa, Keinosuke Ryu, Edwin Choi, Francis John Hornicek, Henry J. Mankin, Lara Milane, Mansoor M. Amiji, and Zhenfeng Duan), Bouvé Faculty Publications (2010)

Background: The use of neo-adjuvant chemotherapy in treating osteosarcoma has improved patients’ average 5 year...

 

PDF

Oxystress inducing antitumor therapeutics via tumor-targeted delivery of PEG-conjugated D-amino acid oxidase., Int J Cancer (2008)

We had developed a H(2)O(2) generating enzyme, polyethylene glycol conjugated D-amino acid oxidase (PEG-DAO), which...

 

PDF

High-loading nanosized micelles of copoly(styrene-maleic acid)-zinc protoporphyrin for targeted delivery of a potent heme oxygenase inhibitor., Biomaterials (2007)

Amphiphilic styrene-maleic acid (SMA) copolymer efficiently formed micelles with a potent heme oxygenase inhibitor-zinc protoporphyrin...

 

PDF

Exploiting the enhanced permeability and retention effect for tumor targeting., Drug Discov Today. (2006)

Of the tumor targeting strategies, the enhanced permeability and retention (EPR) effect of macromolecules is...

 

Combinatorial Designed Nanosystems

Hyaluronic acid based self-assembling nanosystems for CD44 target mediated siRNA delivery to solid tumors., Biomaterials (2013)

Anticancer therapeutics employing RNA interference mechanism holds promising potentials for sequence-specific silencing of target genes....

 

PDF

Combinatorial-designed multifunctional polymeric nanosystems for tumor-targeted therapeutic delivery., Accounts of Chemical Research (2011)

By definition, multifunctional nanosystems include several features within a single construct so that these devices...

 

PDF

Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma (with Michiro Susa, Keinosuke Ryu, Edwin Choi, Francis John Hornicek, Henry J. Mankin, Lara Milane, Mansoor M. Amiji, and Zhenfeng Duan), Bouvé Faculty Publications (2010)

Background: The use of neo-adjuvant chemotherapy in treating osteosarcoma has improved patients’ average 5 year...

 

Oxystress

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Oxystress inducing antitumor therapeutics via tumor-targeted delivery of PEG-conjugated D-amino acid oxidase., Int J Cancer (2008)

We had developed a H(2)O(2) generating enzyme, polyethylene glycol conjugated D-amino acid oxidase (PEG-DAO), which...

 

PDF

Tumor-targeted induction of oxystress for cancer therapy., J Drug Target. (2007)

Reactive oxygen species (ROS), such as superoxide anion radicals (O.-2) and hydrogen peroxide (H2O2) are...

 

PDF

High-loading nanosized micelles of copoly(styrene-maleic acid)-zinc protoporphyrin for targeted delivery of a potent heme oxygenase inhibitor., Biomaterials (2007)

Amphiphilic styrene-maleic acid (SMA) copolymer efficiently formed micelles with a potent heme oxygenase inhibitor-zinc protoporphyrin...

 

Radiolabeled Oligonucleotides for Antisense Imaging

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Radiolabeled oligonucleotides for antisense imaging., Curr Org Synth. (2011)

Oligonucleotides radiolabeled with isotopes emitting γ-rays (for SPECT imaging) or positrons (for PET imaging) can...

 

ScFv Targeting Mesothelioma

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Novel human single chain antibody fragments that are rapidly internalizing effectively target epithelioid and sarcomatoid mesotheliomas., Cancer Res. (2011)

Human antibodies targeting all subtypes of mesothelioma could be useful to image and treat this...

 

Prostate Cancer Targeting

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Targeting prostate cancer cells in vivo using a rapidly internalizing novel human single-chain antibody fragment., J Nucl Med. (2010)

Human antibodies targeting prostate cancer cell surface epitopes may be useful for imaging and therapy....

 

Colon Cancer Screening Using Fluorescence-guided optical coherence tomography imaging

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Fluorescence-guided optical coherence tomography imaging for colon cancer screening: a preliminary mouse study., Biomed Opt Express. (2012)

A new concept for cancer screening has been preliminarily investigated. A cancer targeting agent loaded...

 

Liposomes targeting to epithelioid and sarcomatoid mesothelioma

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The effect of internalizing human single chain antibody fragment on liposome targeting to epithelioid and sarcomatoid mesothelioma., Biomaterials (2011)

Immunoliposomes (ILs) anchored with internalizing human antibodies capable of targeting all subtypes of mesothelioma can...

 

siRNA Delivery

Hyaluronic acid based self-assembling nanosystems for CD44 target mediated siRNA delivery to solid tumors., Biomaterials (2013)

Anticancer therapeutics employing RNA interference mechanism holds promising potentials for sequence-specific silencing of target genes....

 

PDF

Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma (with Michiro Susa, Keinosuke Ryu, Edwin Choi, Francis John Hornicek, Henry J. Mankin, Lara Milane, Mansoor M. Amiji, and Zhenfeng Duan), Bouvé Faculty Publications (2010)

Background: The use of neo-adjuvant chemotherapy in treating osteosarcoma has improved patients’ average 5 year...

 

Nanoparticles

Hyaluronic acid based self-assembling nanosystems for CD44 target mediated siRNA delivery to solid tumors., Biomaterials (2013)

Anticancer therapeutics employing RNA interference mechanism holds promising potentials for sequence-specific silencing of target genes....

 

PDF

Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma (with Michiro Susa, Keinosuke Ryu, Edwin Choi, Francis John Hornicek, Henry J. Mankin, Lara Milane, Mansoor M. Amiji, and Zhenfeng Duan), Bouvé Faculty Publications (2010)

Background: The use of neo-adjuvant chemotherapy in treating osteosarcoma has improved patients’ average 5 year...

 

PDF

Oxystress inducing antitumor therapeutics via tumor-targeted delivery of PEG-conjugated D-amino acid oxidase., Int J Cancer (2008)

We had developed a H(2)O(2) generating enzyme, polyethylene glycol conjugated D-amino acid oxidase (PEG-DAO), which...

 

PDF

High-loading nanosized micelles of copoly(styrene-maleic acid)-zinc protoporphyrin for targeted delivery of a potent heme oxygenase inhibitor., Biomaterials (2007)

Amphiphilic styrene-maleic acid (SMA) copolymer efficiently formed micelles with a potent heme oxygenase inhibitor-zinc protoporphyrin...

 

PDF

Exploiting the enhanced permeability and retention effect for tumor targeting., Drug Discov Today. (2006)

Of the tumor targeting strategies, the enhanced permeability and retention (EPR) effect of macromolecules is...

 

Liposomes

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Exploiting the enhanced permeability and retention effect for tumor targeting., Drug Discov Today. (2006)

Of the tumor targeting strategies, the enhanced permeability and retention (EPR) effect of macromolecules is...

 

Heme Oxygenase,

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High-loading nanosized micelles of copoly(styrene-maleic acid)-zinc protoporphyrin for targeted delivery of a potent heme oxygenase inhibitor., Biomaterials (2007)

Amphiphilic styrene-maleic acid (SMA) copolymer efficiently formed micelles with a potent heme oxygenase inhibitor-zinc protoporphyrin...

 

EPR effect

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Oxystress inducing antitumor therapeutics via tumor-targeted delivery of PEG-conjugated D-amino acid oxidase., Int J Cancer (2008)

We had developed a H(2)O(2) generating enzyme, polyethylene glycol conjugated D-amino acid oxidase (PEG-DAO), which...

 

PDF

High-loading nanosized micelles of copoly(styrene-maleic acid)-zinc protoporphyrin for targeted delivery of a potent heme oxygenase inhibitor., Biomaterials (2007)

Amphiphilic styrene-maleic acid (SMA) copolymer efficiently formed micelles with a potent heme oxygenase inhibitor-zinc protoporphyrin...

 

PDF

Exploiting the enhanced permeability and retention effect for tumor targeting., Drug Discov Today. (2006)

Of the tumor targeting strategies, the enhanced permeability and retention (EPR) effect of macromolecules is...

 

Enhanced Permeability and Retention Effect

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Oxystress inducing antitumor therapeutics via tumor-targeted delivery of PEG-conjugated D-amino acid oxidase., Int J Cancer (2008)

We had developed a H(2)O(2) generating enzyme, polyethylene glycol conjugated D-amino acid oxidase (PEG-DAO), which...

 

PDF

Exploiting the enhanced permeability and retention effect for tumor targeting., Drug Discov Today. (2006)

Of the tumor targeting strategies, the enhanced permeability and retention (EPR) effect of macromolecules is...

 

Oxystress inducing antitumor therapeutics

PDF

Oxystress inducing antitumor therapeutics via tumor-targeted delivery of PEG-conjugated D-amino acid oxidase., Int J Cancer (2008)

We had developed a H(2)O(2) generating enzyme, polyethylene glycol conjugated D-amino acid oxidase (PEG-DAO), which...

 

Polymeric Micelles

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Oxystress inducing antitumor therapeutics via tumor-targeted delivery of PEG-conjugated D-amino acid oxidase., Int J Cancer (2008)

We had developed a H(2)O(2) generating enzyme, polyethylene glycol conjugated D-amino acid oxidase (PEG-DAO), which...

 

PDF

High-loading nanosized micelles of copoly(styrene-maleic acid)-zinc protoporphyrin for targeted delivery of a potent heme oxygenase inhibitor., Biomaterials (2007)

Amphiphilic styrene-maleic acid (SMA) copolymer efficiently formed micelles with a potent heme oxygenase inhibitor-zinc protoporphyrin...

 

PDF

Exploiting the enhanced permeability and retention effect for tumor targeting., Drug Discov Today. (2006)

Of the tumor targeting strategies, the enhanced permeability and retention (EPR) effect of macromolecules is...

 

Lung Cancer

Hyaluronic acid based self-assembling nanosystems for CD44 target mediated siRNA delivery to solid tumors., Biomaterials (2013)

Anticancer therapeutics employing RNA interference mechanism holds promising potentials for sequence-specific silencing of target genes....