An overview of heparin-induced thrombocytopenia

Jennifer L. Donovan, University of Massachusetts Medical School
Maichi T. Tran, Massachusetts College of Pharmacy and Health Sciences
Abir O. Kanaan, University of Massachusetts Medical School

Abstract

Heparin-induced thrombocytopenia (HIT) is an immune-mediated adverse drug reaction to heparin products leading to a prothrombotic state. Devastating clinical sequelae may result, including venous or arterial thromboembolism, limb amputation, and death. Heparin cessation alone is insufficient to manage HIT. Pharmacotherapy with argatroban or lepirudin is essential. This article reviews the pathogenesis, diagnosis, and pharmacotherapy of HIT.