The goal of my research program is to understand the influence of environmental factors on epigenetic mechanisms of gene regulation in determining health and disease in animals and humans. In other words, we focus on the intersection of nature and nurture by investigating gene-environment interactions. My research group will strive to address three key questions: How is the fetal epigenome impacted by the environment? How are these epigenetic changes related to the health or disease status of the offspring? Can optimal maternal dietary conditions be identified to reduce disease risk in adulthood? Our studies center on a class of environmental pollutants important to Utah and the world – polycyclic aromatic hydrocarbons (PAHs), derived from burning of fossil fuels and biomass materials. We also investigate the beneficial effects of certain nutrition supplements and bioactive food components derived from a number of key food crops, several of which are important to Utah agriculture (e.g. apples, onions, various berries, tomatoes), in counter-acting the adverse effects of PAHs to prevent or suppress cancer. My research program is supported by funds from the Utah Agricultural Experiment Station, the National Cancer Institute and the National Institute of Environmental Health Sciences.
Rainbow Trout (Oncorhynchus mykiss) and Ultra-Low Dose Cancer Studies (with D. E. Williams, K. D. Willard, G. A. Orner, J. D. Hendricks, C. Pereira, and G. S. Bailey), Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology (2009)
Genomic Profiling Reveals an Alternate Mechanism for Hepatic Tumor Promotion by Perfluorooctanoic Acid in Rainbow Trout (with S. C. Tilton, G. A. Orner, J. D. Hendricks, and D. E. Williams), Environmental Health Perspectives (2008)
Identification of a Transcriptional Fingerprint of Estrogen Exposure in Rainbow Trout Liver (with D. E. Williams), Toxicological Sciences (2008)
Cloning of Three GnRH Genes and Their mRNA Expressions During Larval Development and Prior to Active Gametogenesis in the Cobia, Rachycentron canadum (with J. S. Mohamed, G. J. Holt, and I. A. Khan), Journal of Molecular Endocrinology (2007)
Ontogeny of the Gastrointestinal Tract and Selected Digestive Enzymes in Cobia (Rachycentron canadum) Larval Development (with C. K. Faulk and G. J. Holt), Journal of Fish Biology (2007)
Contributions to Books